Lectin‐based phototherapy targeting cell surface glycans for pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34362
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is resistant to current treatments but lectin‐based therapy targeting cell surface glycans could be a promising new horizon. Here, we report a novel lectin‐based phototherapy (Lec‐PT) that combines the PDAC targeting… read more here.
Keywords: cell; pancreatic cancer; lectin; targeting cell ... See more keywords
A lectin-based glycomic approach identifies FUT8 as a driver of radioresistance in oesophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Oncology"
DOI: 10.1007/s13402-020-00517-5
Abstract: Purpose Radio-resistance is recognized as a main factor in the failure of radiotherapy in oesophageal squamous cell carcinoma (ESCC). Aberrant cell surface glycosylation has been reported to correlate with radio-resistance in different kinds of tumours.… read more here.
Keywords: radio resistance; lectin based; cell; escc ... See more keywords
Lectin-based biosensors as analytical tools for clinical oncology.
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DOI: 10.1016/j.canlet.2018.08.005
Abstract: The review focus on the use of lectin-based biosensors in the oncology field, and ponders the potentialities of using these devices as analytical tools to monitor the levels of cancer glycobiomarkers in biological fluids, helping… read more here.
Keywords: tools clinical; lectin based; biosensors analytical; analytical tools ... See more keywords
Influence of media composition on recombinant monoclonal IgA1 glycosylation analysed by lectin-based protein microarray and MALDI-MS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biotechnology"
DOI: 10.1016/j.jbiotec.2020.03.009
Abstract: Abstract Glycosylation of therapeutic glycoproteins significantly affects their physico-chemical properties, bioactivity and immunogenicity. The determination of glycan composition is highly important regarding their development and production. Therefore, there is a demand for analytical techniques enabling… read more here.
Keywords: protein microarray; based protein; lectin based; iga1 ... See more keywords
Engineering recombinantly expressed lectin-based antiviral agents
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DOI: 10.3389/fcimb.2022.990875
Abstract: Cyanovirin-N (CV-N), a lectin from Nostoc ellipsosporum was found an infusion inhibitory protein for human immunodeficiency virus (HIV)-1. A tandem-repeat of the engineered domain-swapped dimer bound specific sites at hemagglutinin (HA), Ebola and HIV spike… read more here.
Keywords: lectin; affinity; expressed lectin; engineering recombinantly ... See more keywords