NMR-based insight into galectin-3 binding to endothelial cell adhesion molecule CD146: evidence for non-canonical interactions with the lectin's CRD β-sandwich F-face.
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DOI: 10.1093/glycob/cwz036
Abstract: Galectin-3 (Gal-3) binds to cell adhesion glycoprotein CD146 to promote cytokine secretion and mediate endothelial cell migration. Here, we used NMR 15N-HSQC spectroscopy to investigate binding between 15N-labeled Gal-3 and the extracellular domain (eFL) of… read more here.
Keywords: cd146; endothelial cell; cell adhesion; lectin crd ... See more keywords