Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.
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DOI: 10.1039/c9cc06376e
Abstract: Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug… read more here.
Keywords: multivalent glycoligands; dual specificity; lectin enzyme; glycoligands lectin ... See more keywords