Proteins of the Lectin Pathway of complement activation at the site of injury in subarachnoid hemorrhage compared with peripheral blood
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1728
Abstract: A subarachnoid hemorrhage (SAH) is a debilitating stroke. Activation of the lectin pathway (LP) of the complement system in SAH patients could worsen the prognosis; however, conflicting results have been reported. This potentially reflects that… read more here.
Keywords: site injury; pathway complement; lectin pathway; subarachnoid hemorrhage ... See more keywords
Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-019-00714-4
Abstract: Mannose-binding lectin (MBL)-associated serine protease-2 (MASP-2) is an indispensable enzyme for the activation of the lectin pathway of complement. Its deficiency is classified as a primary immunodeficiency associated to pyogenic bacterial infections, inflammatory lung disease,… read more here.
Keywords: lectin pathway; deficiency; masp deficiency; primary immunodeficiency ... See more keywords
Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab
Sign Up to like & getrecommendations! Published in 2020 at "Immunobiology"
DOI: 10.1016/j.imbio.2020.152001
Abstract: Abstract In COVID-19, acute respiratory distress syndrome (ARDS) and thrombotic events are frequent, life-threatening complications. Autopsies commonly show arterial thrombosis and severe endothelial damage. Endothelial damage, which can play an early and central pathogenic role… read more here.
Keywords: lectin pathway; treatment; pathway inhibitor; covid ... See more keywords
Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00114
Abstract: MASP-1 and MASP-2 are key activator proteases of the complement lectin pathway. The first specific mannose-binding lectin-associated serine protease (MASP) inhibitors had been developed from the 14-amino-acid sunflower trypsin inhibitor (SFTI) peptide by phage display,… read more here.
Keywords: structural plasticity; complement lectin; lectin pathway; directed evolution ... See more keywords
Lectin pathway factors in patients suffering from juvenile idiopathic arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2017.31
Abstract: Both complement activation and certain infections (including those with Yersinia sp.) may contribute to the pathogenesis of juvenile idiopathic arthritis (JIA). We investigated factors specific for the lectin pathway of complement: mannose‐binding lectin (MBL), ficolins… read more here.
Keywords: juvenile idiopathic; jia; lectin pathway; idiopathic arthritis ... See more keywords
The lectin pathway does not contribute to glomerular injury in the nephrotoxic nephritis model.
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology"
DOI: 10.1111/nep.13988
Abstract: AIMS Rapidly progressive crescentic glomerulonephritis occurs in a number systemic and primary glomerular diseases, including anti-glomerular basement membrane disease, anti-neutrophil cytoplasmic antibody vasculitis, and lupus nephritis. Our understanding of pathogenic mechanisms comes from animal models… read more here.
Keywords: nephrotoxic nephritis; lectin pathway; nephritis model; crescentic glomerulonephritis ... See more keywords
Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01041-1
Abstract: The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacological targets. We… read more here.
Keywords: outcome; lectin pathway; masp; mice ... See more keywords
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.714511
Abstract: Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of… read more here.
Keywords: lectin pathway; activation; cov proteins; sars cov ... See more keywords
Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality
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DOI: 10.3389/fimmu.2021.742446
Abstract: Background The SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy. The complement system (CS) activation participates to this hyperinflammatory response. However, it is still unclear… read more here.
Keywords: binding lectin; lectin pathway; mannose binding; complement ... See more keywords
Dengue and the Lectin Pathway of the Complement System
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13071219
Abstract: Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4). Usually, the primary infection is asymptomatic or causes mild dengue fever (DF), while secondary… read more here.
Keywords: dengue lectin; pathway complement; lectin pathway; complement system ... See more keywords