C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847536
Abstract: C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin‐1 cluster, comprising of seven receptors including MICL, CLEC‐2, CLEC‐12B,… read more here.
Keywords: physiological roles; roles involvement; type lectin; disease ... See more keywords
C-Type Lectin Receptors in Phagocytosis.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_198
Abstract: C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates… read more here.
Keywords: type lectin; microbiology; type; receptors phagocytosis ... See more keywords
C-Type Lectin Receptors in Antifungal Immunity.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1580-4_1
Abstract: Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall… read more here.
Keywords: immunity; receptors antifungal; type lectin; type ... See more keywords
Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.03.018
Abstract: Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control of gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, the loss of… read more here.
Keywords: divergent roles; inflammation; type lectin; dectin ... See more keywords
Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00121g
Abstract: The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a… read more here.
Keywords: type lectin; cov spike; lectin receptors; glycomimetic ligands ... See more keywords
C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
Sign Up to like & getrecommendations! Published in 2022 at "Parasite Immunology"
DOI: 10.1111/pim.12951
Abstract: C‐type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by… read more here.
Keywords: type lectin; antifungal immunity; lectin receptors; immune response ... See more keywords
NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s245638
Abstract: Purpose Pathogens consist of a wide variety of evolutionarily conserved molecular structures that are recognized by pattern recognition receptors (PRRs) of innate immunity. Reasonably assuming that no single PRR is ever likely to be the… read more here.
Keywords: mincle; type lectin; vitro vivo; lectin receptors ... See more keywords
C-Type Lectin Receptors-Triggered Antifungal Immunity May Synergize with and Optimize the Effects of Immunotherapy in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s394503
Abstract: Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system worldwide, and there is a lack of effective treatment for late-stage HCC. Recent experimental studies have demonstrated that dysfunction… read more here.
Keywords: hepatocellular carcinoma; type lectin; antifungal immunity; lectin receptors ... See more keywords
Myeloid C-Type Lectin Receptors in Tuberculosis and HIV Immunity: Insights Into Co-infection?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00263
Abstract: C-type lectin receptors (CLRs) are carbohydrate binding pattern recognition receptors (PRRs) which play a central role in host recognition of pathogenic microorganisms. Signaling through CLRs displayed on antigen presenting cells dictates important innate and adaptive… read more here.
Keywords: lectin receptors; infection; type lectin; mtb hiv ... See more keywords
A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02098
Abstract: Myeloid C-type lectin receptors (CLRs) comprise a family of receptors expressed by immune myeloid cells that share homologous C-type lectin domains. The implication of these CLRs in the regulation of homeostasis and activation of myeloid… read more here.
Keywords: type; lectin receptors; type lectin; myeloid type ... See more keywords
Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.798214
Abstract: Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans… read more here.
Keywords: lectin receptors; type lectin; current state; state carbohydrate ... See more keywords