Eight weeks of ledipasvir/sofosbuvir is effective for selected patients with genotype 1 hepatitis C virus infection
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DOI: 10.1002/hep.29005
Abstract: Eight weeks duration of ledipasvir/sofosbuvir (LDV/SOF) can be considered in genotype 1 hepatitis C virus–infected patients who are treatment‐naive, do not have cirrhosis, and have a pretreatment viral load read more here.
Keywords: ldv sof; eight weeks; treatment; relapse ... See more keywords
Safety and Efficacy of Ledipasvir–Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6‐11
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30123
Abstract: Currently, there are no interferon‐free treatments available for hepatitis C virus (HCV)–infected patients younger than 12 years. We evaluated the safety and effectiveness of the all‐oral regimen ledipasvir–sofosbuvir ± ribavirin in HCV‐infected children aged 6… read more here.
Keywords: hepatitis; hcv; safety; sofosbuvir ... See more keywords
Ledipasvir plus sofosbuvir as salvage therapy for HCV genotype 1 failures to prior NS5A inhibitors regimens
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DOI: 10.1002/jmv.24767
Abstract: There is little information on retreatment efficacy and predictors of the combination of ledipasvir and sofosbuvir (ledipasvir/sofosbuvir) for patients who fail to respond to NS5A inhibitors. NS5A resistance variants are known to persist for long… read more here.
Keywords: response; prior ns5a; treatment; hcv genotype ... See more keywords
Ledipasvir/Sofosbuvir: A Review in Chronic Hepatitis C
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DOI: 10.1007/s40265-018-0864-z
Abstract: Oral once-daily, fixed-dose, ledipasvir/sofosbuvir (Harvoni®) [± ribavirin] is approved in several countries for the treatment of chronic hepatitis C (CHC) in adults and adolescents aged 12 to read more here.
Keywords: ribavirin; infection; sofosbuvir; ledipasvir sofosbuvir ... See more keywords
Effectiveness and safety of ledipasvir/sofosbuvir±ribavirin in the treatment of HCV infection: The real-world HARVEST study.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2017.04.004
Abstract: BACKGROUND To evaluate the effectiveness and safety of ledipasvir/sofosbuvir (LDV/SOF)±ribavirin (RBV) regimen in a real-world setting. METHODS Patients received a fixed-dose combination tablet containing LDV and SOF with or without RBV, for 8, 12 or… read more here.
Keywords: real world; effectiveness safety; treatment; ledipasvir sofosbuvir ... See more keywords
Effectiveness of ledipasvir/sofosbuvir in real-world patients with chronic hepatitis C: a collaborative treatment approach.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.01.016
Abstract: The effectiveness of ledipasvir/sofosbuvir (LDV/SOF) in routine use in clinical practice for the management of chronic hepatitis C virus (HCV) has not been well described. Data with prior agents suggest that management of HCV using… read more here.
Keywords: chronic hepatitis; ldv sof; treatment; effectiveness ledipasvir ... See more keywords
Ledipasvir-sofosbuvir in Adolescents With Chronic Hepatitis C and Hematological Malignancies Undergoing Chemotherapy
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DOI: 10.1097/mpg.0000000000003406
Abstract: ABSTRACT Objectives: In children with hematological malignancies, chronic hepatitis C virus (HCV) infection has been associated with more rapid liver disease progression and higher risk of malignancy relapse due to chemotherapy interruption. We evaluated the… read more here.
Keywords: ledipasvir sofosbuvir; adolescents chronic; chronic hepatitis; hcv ... See more keywords
Retrospective multicentre study on the effectiveness of first-line direct-acting antivirals against hepatitis C virus genotype-1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical pharmacy and therapeutics"
DOI: 10.1111/jcpt.13624
Abstract: WHAT IS KNOWN AND OBJECTIVE In Japan, ledipasvir/sofosbuvir, elbasvir/grazoprevir and glecaprevir/pibrentasvir are recommended as first-line treatments for patients with untreated hepatitis C virus genotype 1. Although they have demonstrated a high efficacy in clinical trials,… read more here.
Keywords: response; glecaprevir pibrentasvir; ledipasvir sofosbuvir; treatment ... See more keywords
Investigation of Pharmacokinetic Interactions between Doravirine and Elbasvir-Grazoprevir and Ledipasvir-Sofosbuvir
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DOI: 10.1128/aac.02491-18
Abstract: Doravirine is a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Due to the high prevalence of HIV-1 and hepatitis C virus (HCV) coinfection and coadministration of HIV-1… read more here.
Keywords: ledipasvir sofosbuvir; doravirine; elbasvir grazoprevir; grazoprevir ledipasvir ... See more keywords
Sexual Dysfunction in a Patient Taking Ledipasvir/Sofosbuvir for the Treatment of Hepatitis C: A Case Report
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DOI: 10.1177/0897190017744421
Abstract: Sexual dysfunction is a bothersome side effect of several medications, though it has not yet been reported with the use of ledipasvir/sofosbuvir for the treatment of hepatitis C. However, sexual dysfunction is a potentially unrecognized… read more here.
Keywords: sexual dysfunction; hepatitis; treatment; dysfunction ... See more keywords
Severe Steroid-responsive Skin Disorders Related to Ledipasvir and Sofosbuvir for HCV
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DOI: 10.2169/internalmedicine.9744-17
Abstract: Combination therapy with ledipasvir and sofosbuvir (LDV/SOF), direct-acting antiviral agents, is highly effective against hepatitis C virus genotype 1 infection. Although LDV/SOF is safer than conventional treatment, reports have indicated that LDV/SOF was discontinued in… read more here.
Keywords: skin disorders; ldv sof; treatment; sof ... See more keywords