A peptide inhibitor of macrophage migration in atherosclerosis purified from the leech Whitmania pigra.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112723
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Atherosclerosis has become a worldwide public health problem that seriously threatens human health. Leech is traditional Chinese medicine that can be utilized to treat cardiovascular disease. Based on the anti-atherosclerosis activity of leech… read more here.
Keywords: macrophage migration; leech whitmania; leech peptide; migration ... See more keywords
Life without blood: Molecular and functional analysis of hirudins and hirudin‐like factors of the Asian non‐hematophagous leech Whitmania pigra
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15762
Abstract: Several leech species of the genera Hirudo, Hirudinaria, and Whitmania are widely used in traditional Chinese medicine (TCM) for the oral treatment of disorders associated with blood stasis. Among them, the non‐hematophagous leech Whitmania pigra… read more here.
Keywords: hematophagous leech; whitmania; non hematophagous; whitmania pigra ... See more keywords
WPK5, a Novel Kunitz-Type Peptide from the Leech Whitmania pigra Inhibiting Factor XIa, and Its Loop-Replaced Mutant to Improve Potency
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DOI: 10.3390/biomedicines9121745
Abstract: Kunitz-type proteins or peptides have been found in many blood-sucking animals, but the identity of them in leeches remained elusive. In the present study, five Kunitz-type peptides named WPK1-WPK5 were identified from the leech Whitmania… read more here.
Keywords: loop; wpk5; potency; kunitz type ... See more keywords