Silencing of long noncoding RNA LEF1‐AS1 prevents the progression of hepatocellular carcinoma via the crosstalk with microRNA‐136‐5p/WNK1
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29503
Abstract: Long noncoding RNAs (lncRNAs) have been recognized as cancer‐associated biological molecules, favoring hepatocellular carcinoma (HCC) progression. This study was conducted to elucidate the effects lncRNA lymphoid enhancer‐binding Factor 1 antisense RNA (LEF1‐AS1) on the pathological… read more here.
Keywords: hcc; wnk1; lncrna lef1; lef1 as1 ... See more keywords
Sox9 and Lef1 regulate the fate and behavior of airway glandular progenitors in response to injury.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac038
Abstract: Cartilaginous airways of larger mammals and the mouse trachea contain at least three well-established stem cell compartments including basal cells (BC) of the surface airway epithelium (SAE) and ductal and myoepithelial cells of the submucosal… read more here.
Keywords: sae; sox9; behavior; glandular progenitors ... See more keywords
LEF1 drives a central memory program and supports antitumor activity of natural killer T cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0333
Abstract: Vα24-invariant natural killer T cells (NKTs) possess innate antitumor properties that can be exploited for cancer immunotherapy. We have shown previously that the CD62L+ central memory-like subset of these cells drives the in vivo antitumor… read more here.
Keywords: antitumor; central memory; natural killer; program ... See more keywords
The Distinct Role of Tcfs and Lef1 in the Self-Renewal or Differentiation of Mouse Embryonic Stem Cells
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DOI: 10.15283/ijsc20044
Abstract: Background and Objectives Tcfs and Lef1 are DNA-binding transcriptional factors in the canonical Wnt signaling pathway. In the absence of β-catenin, Tcfs and Lef1 generally act as transcriptional repressors with co-repressor proteins such as Groucho,… read more here.
Keywords: role tcfs; lef1; tcfs lef1; differentiation ... See more keywords
MiR-34a-5p Inhibits Proliferation, Migration, Invasion and Epithelial-mesenchymal Transition in Esophageal Squamous Cell Carcinoma by Targeting LEF1 and Inactivation of the Hippo-YAP1/TAZ Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.39861
Abstract: Background: Our previous studies reported that lymphoid enhancer-binding factor 1 (LEF1) was upregulated in esophageal squamous cell carcinoma (ESCC) and the positive expression of LEF1 was correlated with aberrant clinicopathological characteristics in ESCC patients. However,… read more here.
Keywords: proliferation migration; mir 34a; escc; lef1 ... See more keywords