An overview of lefamulin for the treatment of community acquired bacterial pneumonia
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DOI: 10.1080/14656566.2020.1714592
Abstract: ABSTRACT Introduction Lefamulin is a novel antibiotic that belongs to the pleuromutilin class with excellent activity against all microorganisms, including atypical pathogens, that cause community-acquired pneumonia (CAP). Areas covered This article reviews the spectrum of… read more here.
Keywords: lefamulin; treatment; overview lefamulin; community acquired ... See more keywords
Tissue Distribution of [14C]-Lefamulin into the Urogenital Tract in Rats
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DOI: 10.1128/aac.00355-22
Abstract: Lefamulin, a semisynthetic pleuromutilin antibiotic approved in the United States, Canada, and Europe for intravenous and oral treatment of community-acquired bacterial pneumonia, is highly active in vitro against bacterial pathogens that cause sexually transmitted infections… read more here.
Keywords: urogenital tract; lefamulin; 14c lefamulin; male female ... See more keywords
Lefamulin: The First Systemic Pleuromutilin Antibiotic
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DOI: 10.1177/1060028020932521
Abstract: Objective: To review the pharmacology, microbiology, efficacy, and safety of lefamulin. Data Sources: A literature search was performed using PubMed and Google Scholar (2010 to end-April 2020) with the search terms BC-3781 and lefamulin. Other… read more here.
Keywords: lefamulin; first systemic; lefamulin first; pleuromutilin antibiotic ... See more keywords
In vitro Activity of Lefamulin Against the Common Respiratory Pathogens Isolated From Mainland China During 2017–2019
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DOI: 10.3389/fmicb.2020.578824
Abstract: Purpose Lefamulin is a novel antibiotic approved by the U.S. Food and Drug Administration in 2019 for the treatment of community-acquired bacterial pneumonia (CABP). In this study we evaluated the in vitro antimicrobial activity of… read more here.
Keywords: lefamulin; mic50; respiratory pathogens; activity lefamulin ... See more keywords
Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections
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DOI: 10.3389/fphar.2022.1035841
Abstract: The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is seriously threatening the treatment and control of gonorrhea globally. Novel treatment options are essential, coupled with appropriate methods to pharmacodynamically examine the efficacy and… read more here.
Keywords: neisseria gonorrhoeae; gonorrhea; lefamulin; resistance ... See more keywords