Leflunomide-induced recurrent-transient ischaemic attacks in a patient with rheumatoid arthritis: first case report
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02907-y
Abstract: Certain drugs are known to be associated with increased risk of cerebrovascular disease by having a prothrombotic effect, causing vasculopathy, altering blood pressure or the coagulation cascade [1]; these phenomena are a direct manifestation of… read more here.
Keywords: ischaemic attacks; leflunomide; rheumatoid arthritis; transient ischaemic ... See more keywords
Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.051
Abstract: Aryl hydrocarbon receptor (AhR) has been increasingly recognized to play a crucial role in normal physiological homeostasis. Additionally, disrupted AhR signaling leads to several pathological states in the lung and liver. AhR activation transcriptionally induces… read more here.
Keywords: leflunomide; ahr; aryl hydrocarbon; enzyme ... See more keywords
Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2079770
Abstract: Abstract Despite the fact of availability of several treatments for breast cancer, most of them fail to attain the desired therapeutic response due to their poor bioavailability, high doses, non-selectivity and as a result systemic… read more here.
Keywords: leflunomide; lef; breast cancer; cancer management ... See more keywords
Methotrexate, leflunomide, and tacrolimus use and the progression of rheumatoid arthritis-associated interstitial lung disease.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac651
Abstract: OBJECTIVE To examine the association between methotrexate, leflunomide, and tacrolimus use and the progression of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD). METHODS The Korean RA-ILD cohort prospectively enrolled patients with RA-associated ILD at multiple… read more here.
Keywords: leflunomide; disease; progression; lung ... See more keywords
P03 Leflunomide treatment for inflammatory bowel disease and intestinal failure caused by TTC7A deficiency
Sign Up to like & getrecommendations! Published in 2023 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2023-nppg.3
Abstract: TTC7A deficiency Ultra-rare autosomal-recessive variants in tetratricopeptide repeat domain 7A gene (TTC7A) have been discovered in patients presenting with severe intestinal disease. Mutations in the TTC7A gene cause intestinal epithelial and immune defects resulting in… read more here.
Keywords: leflunomide; ttc7a deficiency; leflunomide treatment; gastroenterology ... See more keywords
Leflunomide-Induced Immune-Mediated Necrotizing Myopathy in a Patient With Rheumatoid Arthritis: A Case Report
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Investigative Medicine High Impact Case Reports"
DOI: 10.1177/23247096221150636
Abstract: Immune-mediated necrotizing myopathy (IMNM) is a subtype of inflammatory myopathy that is characterized by proximal muscle weakness, markedly elevated serum creatine kinase, myopathic electromyographic findings, and muscle biopsies revealing necrosis or regeneration with sparse inflammatory… read more here.
Keywords: necrotizing myopathy; leflunomide; immune mediated; mediated necrotizing ... See more keywords
Performance of leflunomide as a steroid-sparing agent in giant cell arteritis: A single-center, open-label study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1069013
Abstract: Background The management of giant cell arteritis (GCA) remains challenging and many patients require prolonged glucocorticoid treatment due to high disease relapse rates. We aimed to evaluate the role of leflunomide as a steroid-sparing agent… read more here.
Keywords: leflunomide steroid; leflunomide; giant cell; group ... See more keywords