Legumain Knockout Protects Against Aβ1-42-Induced AD-like Cognitive Deficits and Synaptic Plasticity Dysfunction Via Inhibiting Neuroinflammation Without Cleaving APP.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02219-3
Abstract: Neuroinflammation is the important pathological feature of Alzheimer's disease (AD). Legumain, a lysosomal cysteine protease, plays an important role in neuroinflammation during ischemic stroke and depressive disorder. Legumain is involved in AD process through cleaving… read more here.
Keywords: neuroinflammation; legumain knockout; legumain; synaptic plasticity ... See more keywords
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112219
Abstract: Cognitive impairment has been widely recognized as a central feature of depression. Legumain, a lysosomal cysteine protease, plays an important role in cancer, atherosclerosis, inflammation and other pathological conditions. Meanwhile, it has been reported that… read more here.
Keywords: legumain; cognitive impairment; cus induced; induced cognitive ... See more keywords
Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Letters"
DOI: 10.1016/j.canlet.2019.12.013
Abstract: Macrophages serve as the first line of communication between tumors and the rest of the immune system, and understanding the interplay between macrophage and tumor cells is essential for developing novel macrophage-based strategy against tumor.… read more here.
Keywords: activation; tumor cells; senescence tumor; tumor ... See more keywords
Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Protein expression and purification"
DOI: 10.1016/j.pep.2018.05.003
Abstract: Legumain (LGMN) is a lysosomal protease that can specifically hydrolyze proteins after carboxyl-terminal asparagine residues. It has been reported that Legumain is highly expressed in many human tumors and promotes the migratory and invasive activity… read more here.
Keywords: protein; small molecule; expression; pichia pastoris ... See more keywords
Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis
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DOI: 10.1111/acel.13574
Abstract: Aging is an independent risk factor for acute kidney injury and subsequent chronic kidney diseases, while the underlying mechanism is still elusive. Here, we found that renal tubules highly express a conserved lysosomal endopeptidase, legumain,… read more here.
Keywords: legumain; loss legumain; senescence; legumain deficiency ... See more keywords
Serum Legumain Is Associated with Peripheral Artery Disease in Patients with Type 2 Diabetes
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DOI: 10.1155/2021/5651469
Abstract: Background Legumain is related to carotid atherosclerotic plaques and may be a new biomarker of carotid atherosclerosis. However, the association between legumain and peripheral artery disease (PAD) of lower extremity has been less studied. This… read more here.
Keywords: peripheral artery; serum legumain; pad; artery disease ... See more keywords
Active legumain promotes invasion and migration of neuroblastoma by regulating epithelial-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0012
Abstract: Abstract Neuroblastoma (NB) is a commonly occurring malignancy in children. Epithelial-mesenchymal transition (EMT) is an adaptive change in promoting tumor metastasis. As an important factor in regulating tumor metastasis, whether legumain could promote metastasis of… read more here.
Keywords: invasion migration; mesenchymal transition; active legumain; legumain ... See more keywords
Legumain Promotes Atherosclerotic Vascular Remodeling
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DOI: 10.3390/ijms20092195
Abstract: Legumain, a recently discovered cysteine protease, is increased in both carotid plaques and plasma of patients with carotid atherosclerosis. Legumain increases the migration of human monocytes and human umbilical vein endothelial cells (HUVECs). However, the… read more here.
Keywords: legumain promotes; vascular remodeling; expression; atherosclerotic vascular ... See more keywords