Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.05.012
Abstract: BACKGROUND Uterine leiomyomas, the most common tumors of the female reproductive system, feature excessive deposition of disordered stiff extracellular matrix (ECM) and fundamentally altered mechanical signaling pathways . Specifically, these alterations impact the normal dynamic… read more here.
Keywords: leiomyoma cells; altered mechanotransduction; simvastatin; mechanical signaling ... See more keywords
Simvastatin, at clinically relevant concentrations, affects human uterine leiomyoma growth and extracellular matrix production.
Sign Up to like & getrecommendations! Published in 2018 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2018.07.024
Abstract: OBJECTIVE To observe the antifibroid effects of therapeutic concentrations of simvastatin, which interferes with cholesterol biosynthesis, a known precursor of five major classes of steroid hormones, including progesterone and estrogen, which play a major role… read more here.
Keywords: leiomyoma cells; production; simvastatin; extracellular matrix ... See more keywords
Hypoxia induces proliferation via NOX4-Mediated oxidative stress and TGF-β3 signaling in uterine leiomyoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2061967
Abstract: Abstract Uterine leiomyomas, the most common tumors of the female reproductive system, are known to have a hypoxic microenvironment. However, the role of such environment in leiomyoma pathobiology remains unknown. The objective was to determine… read more here.
Keywords: leiomyoma; leiomyoma cells; proliferation; hypoxia induces ... See more keywords
Effects of progesterone receptor on proliferation of uterine leiomyoma cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biological regulators and homeostatic agents"
DOI: 10.23812/19-170-a.
Abstract: In order to study the mechanism of the effect of progesterone receptor on the growth of primary uterine leiomyoma cells, the primary cells were extracted from uterine leiomyoma cells and identified by immunohistochemistry (IHC). Mitochondrial… read more here.
Keywords: uterine leiomyoma; progesterone receptor; leiomyoma cells; receptor ... See more keywords