Gene fusions characterize a subset of uterine cellular leiomyomas
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.1002/gcc.22888
Abstract: Uterine leiomyomas are the most common benign tumor of the female genital tract. Previous studies have shown that conventional leiomyomas often harbor‐specific alterations including rearrangements involving HMGA2. Cellular leiomyomas are a variant of uterine leiomyoma… read more here.
Keywords: gene fusions; leiomyomas; fusions characterize; uterine cellular ... See more keywords
Genomic profile analysis of leiomyomas with bizarre nuclei and fumarate hydratase deficient leiomyomas: Strengths, weaknesses, and limitations of array‐CGH interpretation
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DOI: 10.1002/gcc.23229
Abstract: A close relationship has been demonstrated between genomic complexity and clinical outcome in uterine smooth muscle tumors. We studied the genomic profiles by array‐CGH of 28 fumarate hydratase deficient leiomyomas and 37 leiomyomas with bizarre… read more here.
Keywords: leiomyomas; leiomyomas bizarre; fumarate hydratase; array cgh ... See more keywords
The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2019.05.018
Abstract: BACKGROUND Although uterine leiomyomas and leiomyosarcomas are considered biologically-unrelated tumors, they share morphological and histological characteristics that complicate their differential diagnosis. The long-term therapeutic option for leiomyoma is laparoscopic myomectomy with morcellation, particularly for patients… read more here.
Keywords: leiomyosarcomas using; leiomyomas; uterine leiomyomas; leiomyomas leiomyosarcomas ... See more keywords
The role of adipokines in leiomyomas development.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2021.104693
Abstract: INTRODUCTION Many women of premenopausal age suffer from uterine leiomyomas, which are benign tumors of the uterus. Despite the high prevalence of uterine leiomyomas underlying pathogenesis mechanisms are not fully elucidated. Early data showed a… read more here.
Keywords: leiomyomas; leiomyomas development; role adipokines; adipokines leiomyomas ... See more keywords
Global metabolomic profiling of uterine leiomyomas
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DOI: 10.1038/bjc.2017.361
Abstract: Background:Uterine leiomyomas can be classified into molecularly distinct subtypes according to their genetic triggers: MED12 mutations, HMGA2 upregulation, or inactivation of FH. The aim of this study was to identify metabolites and metabolic pathways that… read more here.
Keywords: metabolomic profiling; leiomyomas; uterine leiomyomas; profiling uterine ... See more keywords
Leiomyomas of the Gastrointestinal Tract: A Clinicopathologic Review
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqae129.119
Abstract: Leiomyomas are benign smooth muscle tumors that can be found anywhere along the gastrointestinal tract (GIT). We undertook a retrospective study to investigate the incidence of GIT leiomyomas and to gain better understanding of their… read more here.
Keywords: leiomyomas; leiomyomas showed; gastrointestinal tract; pathology ... See more keywords
Prevalence of occult leiomyosarcomas and atypical leiomyomas after laparoscopic morcellation of leiomyomas in reproductive-age women
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DOI: 10.1093/humrep/dex258
Abstract: STUDY QUESTION What is the prevalence of leiomyosarcomas and atypical leiomyomas after laparoscopic morcellation of fibroids in reproductive age women? SUMMARY ANSWER No case of leiomyosarcomas but seven atypical leiomyomas were found in 1216 subjects.… read more here.
Keywords: leiomyomas; leiomyosarcomas atypical; laparoscopic morcellation; morcellation ... See more keywords
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
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DOI: 10.1097/aog.0000000000004401
Abstract: Uterine leiomyomas (fibroids) are the most common solid and symptomatic neoplasm in women. They are the leading indication for hysterectomy (1, 2), which is a definitive and effective surgical treatment for leiomyoma. However, many patients… read more here.
Keywords: management; uterine leiomyomas; practice bulletin; leiomyomas ... See more keywords
Treatment of cutaneous leiomyomas with botulinum toxin. Case report and review of literature
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DOI: 10.1111/dth.15121
Abstract: Dear Editor, A 36-year-old male with clinical and genetic diagnose of hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) also known as Reed syndrome (p.Arg233Cys pathogenic variant in FH gen, associated with HLRCC), consulted for… read more here.
Keywords: leiomyomas; treatment; botulinum toxin; cutaneous leiomyomas ... See more keywords
Abstract 996: Identification of molecular biomarkers differentiating malignant uterine leiomyosarcoma from benign leiomyoma
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DOI: 10.1158/1538-7445.am2023-996
Abstract: Uterine leiomyosarcomas are rare, aggressive cancers that represent the most common type of uterine sarcomas. They frequently harbor genetic alterations in TP53, RB1, PTEN, and ATRX. Their benign counterpart, uterine leiomyomas (or fibroids) are very… read more here.
Keywords: leiomyoma; molecular biomarkers; leiomyosarcomas; malignant uterine ... See more keywords
Diagnostic Value and Interobserver Reproducibility of Histopathological Features in Fumarate Hydratase-Deficient Uterine Leiomyomas
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DOI: 10.3390/diagnostics15233006
Abstract: Background/Objectives: Fumarate hydratase-deficient leiomyomas (dFH-LMs) are a rare subtype of uterine smooth muscle tumors (USMTs) with implications for hereditary leiomatosis and renal cell carcinoma (HLRCC). Although several morphologic clues have been proposed, their diagnostic reproducibility… read more here.
Keywords: leiomyomas; fumarate hydratase; interobserver reproducibility; dfh lms ... See more keywords