Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11880
Abstract: Lipophosphoglycan (LPG), the major Leishmania glycoconjugate, induces pro‐inflammatory/immunosuppressive innate immune responses. Here, we evaluated functional/biochemical LPG properties from six Leishmania amazonensis strains from different hosts/clinical forms. LPGs from three strains (GV02, BA276, and LV79) had… read more here.
Keywords: susceptibility antileishmanial; clinical forms; amazonensis; side chains ... See more keywords
Leishmania (Leishmania) amazonensis and Leishmania (Leishmania) infantum sialic acids enhance macrophage infection
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.12269
Abstract: Leishmaniases affect millions of people around the world, caused by Leishmania parasites. Leishmania are transmitted by female sandflies from Phlebotominae subfamily during their blood meals. In mammals, promastigotes are phagocytosed mainly by macrophages, differentiate into… read more here.
Keywords: leishmania; leishmania amazonensis; leishmania leishmania; infantum ... See more keywords
Macrophage Protein Disulfide Isomerase Increases Infection by Leishmania amazonensis
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70020
Abstract: Leishmania spp. are protozoans with a digenetic life cycle responsible for causing tegumentary and visceral leishmaniasis. Leishmania (L.) amazonensis is the second most prevalent dermotropic species in Brazil. Infection in humans and other mammals takes… read more here.
Keywords: disulfide isomerase; protein disulfide; pdi; infection ... See more keywords
New Dichalcogenides Induce Oxidative Stress and Cell Death of Leishmania amazonensis
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DOI: 10.1002/ddr.70018
Abstract: Leishmaniasis are caused by protozoa of the genus Leishmania and affect millions of people worldwide. They are considered neglected diseases that primarily impact individuals in tropical and subtropical regions. The drugs currently available for treating… read more here.
Keywords: oxidative stress; leishmania amazonensis; new dichalcogenides; cell death ... See more keywords
High dilutions of antimony modulate cytokines production and macrophage – Leishmania (L.) amazonensis interaction in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.01.004
Abstract: Background: In previous results mice treated with high dilutions of antimony presented reduction of monocyte migration to the site of infection with increase in B lymphocytes population in the local lymph node. Aims: To know… read more here.
Keywords: amazonensis interaction; high dilutions; production; cytokines production ... See more keywords
In vitro effect of Bothrops leucurus lectin (BLL) against Leishmania amazonensis and Leishmania braziliensis infection.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.08.064
Abstract: Leishmania amazonensis and Leishmania braziliensis are the main causative agents of American Tegumentary Leishmaniasis (ATL) in Brazil. As intracellular parasites, the infection by Leishmania species is dependent on the host immune response and the immunotherapy… read more here.
Keywords: braziliensis; leishmania amazonensis; bll; amazonensis leishmania ... See more keywords
Leishmania amazonensis response to artemisinin and derivatives.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102218
Abstract: The worldwide presence of Leishmania parasites increases in the poorest regions. Current leishmaniasis treatments are unsatisfactory due to resistance development, side effects and cost. Herein, we describe the in vitro activity of artemisinin (ART), artemether… read more here.
Keywords: ic50; leishmania amazonensis; amazonensis response; response artemisinin ... See more keywords
Amentoflavone isolated from Selaginella sellowii Hieron induces mitochondrial dysfunction in Leishmania amazonensis promastigotes.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102458
Abstract: Leishmaniasis chemotherapy is a bottleneck in disease treatment. Although available, chemotherapy is limited, toxic, painful, and does not lead to parasite clearance, with parasite resistance also being reported. Therefore, new therapeutic options are being investigated,… read more here.
Keywords: amazonensis; amentoflavone; leishmania amazonensis; mitochondrial dysfunction ... See more keywords
Phototoxic effect of aluminium-chlorine and aluminium-hydroxide phthalocyanines on Leishmania (l.) amazonensis.
Sign Up to like & getrecommendations! Published in 2018 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2017.12.008
Abstract: This study investigated the activity of photosensitive phthalocyanines on promastigotes and amastigotes of Leishmania (L.) amazonensis. Aluminum phthalocyanine chloride (AlPcCl), Aluminum phthalocyanine hydroxide (AlPcOH) and zinc phthalocyanine (PcZn) were tested in the presence (matte red… read more here.
Keywords: leishmania amazonensis; aluminium; alpccl alpcoh; hydroxide ... See more keywords
In vitro activity evaluation of seven Brazilian Asteraceae against cancer cells and Leishmania amazonensis
Sign Up to like & getrecommendations! Published in 2019 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2018.11.008
Abstract: Abstract Natural products are a very productive leading source of compounds for the development of medicines. The aim of this research was to investigate the in vitro antiproliferative and antileishmanial activities of 21 extracts from… read more here.
Keywords: leishmania amazonensis; cancer; activity; vitro ... See more keywords
Characterization of Leishmania (L.) amazonensis oligopeptidase B and its role in macrophage infection
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022000816
Abstract: Abstract Abstract Leishmania spp. are parasitic protozoa that cause leishmaniasis, a disease endemic in 98 countries. Leishmania promastigotes are transmitted by the vector and differentiate into amastigotes within phagocytic cells of the vertebrate host. To… read more here.
Keywords: role; infection; leishmania; characterization leishmania ... See more keywords