Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11880
Abstract: Lipophosphoglycan (LPG), the major Leishmania glycoconjugate, induces pro‐inflammatory/immunosuppressive innate immune responses. Here, we evaluated functional/biochemical LPG properties from six Leishmania amazonensis strains from different hosts/clinical forms. LPGs from three strains (GV02, BA276, and LV79) had… read more here.
Keywords: susceptibility antileishmanial; clinical forms; amazonensis; side chains ... See more keywords
High dilutions of antimony modulate cytokines production and macrophage – Leishmania (L.) amazonensis interaction in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.01.004
Abstract: Background: In previous results mice treated with high dilutions of antimony presented reduction of monocyte migration to the site of infection with increase in B lymphocytes population in the local lymph node. Aims: To know… read more here.
Keywords: amazonensis interaction; high dilutions; production; cytokines production ... See more keywords
In vitro effect of Bothrops leucurus lectin (BLL) against Leishmania amazonensis and Leishmania braziliensis infection.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.08.064
Abstract: Leishmania amazonensis and Leishmania braziliensis are the main causative agents of American Tegumentary Leishmaniasis (ATL) in Brazil. As intracellular parasites, the infection by Leishmania species is dependent on the host immune response and the immunotherapy… read more here.
Keywords: braziliensis; leishmania amazonensis; bll; amazonensis leishmania ... See more keywords
Leishmania amazonensis response to artemisinin and derivatives.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102218
Abstract: The worldwide presence of Leishmania parasites increases in the poorest regions. Current leishmaniasis treatments are unsatisfactory due to resistance development, side effects and cost. Herein, we describe the in vitro activity of artemisinin (ART), artemether… read more here.
Keywords: ic50; leishmania amazonensis; amazonensis response; response artemisinin ... See more keywords
Amentoflavone isolated from Selaginella sellowii Hieron induces mitochondrial dysfunction in Leishmania amazonensis promastigotes.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102458
Abstract: Leishmaniasis chemotherapy is a bottleneck in disease treatment. Although available, chemotherapy is limited, toxic, painful, and does not lead to parasite clearance, with parasite resistance also being reported. Therefore, new therapeutic options are being investigated,… read more here.
Keywords: amazonensis; amentoflavone; leishmania amazonensis; mitochondrial dysfunction ... See more keywords
Phototoxic effect of aluminium-chlorine and aluminium-hydroxide phthalocyanines on Leishmania (l.) amazonensis.
Sign Up to like & getrecommendations! Published in 2018 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2017.12.008
Abstract: This study investigated the activity of photosensitive phthalocyanines on promastigotes and amastigotes of Leishmania (L.) amazonensis. Aluminum phthalocyanine chloride (AlPcCl), Aluminum phthalocyanine hydroxide (AlPcOH) and zinc phthalocyanine (PcZn) were tested in the presence (matte red… read more here.
Keywords: leishmania amazonensis; aluminium; alpccl alpcoh; hydroxide ... See more keywords
In vitro activity evaluation of seven Brazilian Asteraceae against cancer cells and Leishmania amazonensis
Sign Up to like & getrecommendations! Published in 2019 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2018.11.008
Abstract: Abstract Natural products are a very productive leading source of compounds for the development of medicines. The aim of this research was to investigate the in vitro antiproliferative and antileishmanial activities of 21 extracts from… read more here.
Keywords: leishmania amazonensis; cancer; activity; vitro ... See more keywords
Characterization of Leishmania (L.) amazonensis oligopeptidase B and its role in macrophage infection
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022000816
Abstract: Abstract Abstract Leishmania spp. are parasitic protozoa that cause leishmaniasis, a disease endemic in 98 countries. Leishmania promastigotes are transmitted by the vector and differentiate into amastigotes within phagocytic cells of the vertebrate host. To… read more here.
Keywords: role; infection; leishmania; characterization leishmania ... See more keywords
Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00976
Abstract: Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects… read more here.
Keywords: salvia cuspidata; amazonensis; leishmania; activity ... See more keywords
Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40804
Abstract: Leishmaniasis is a highly diverse group of diseases caused by kinetoplastid of the genus Leishmania. These parasites are taxonomically diverse, with human pathogenic species separated into two subgenera according to their development site inside the… read more here.
Keywords: leishmaniasis; leishmania amazonensis; visceral leishmaniasis; leishmania leishmania ... See more keywords
The Ecto-5′nucleotidase/CD73 Mediates Leishmania amazonensis Survival in Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/9928362
Abstract: Endogenous nucleotides produced by various group of cells under inflammatory conditions act as potential danger signals in vivo. Extracellularly released nucleotides such as ATP are rapidly hydrolyzed to adenosine by the coordinated ectonucleotidase activities of… read more here.
Keywords: cd73; ecto nucleotidase; nucleotidase cd73; cd39 cd73 ... See more keywords