Dihydroartemisinin, an active metabolite of artemisinin, interferes with Leishmania braziliensis mitochondrial bioenergetics and survival.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-020-07019-1
Abstract: Leishmaniasis is one of the most neglected parasitic infections of the world and current therapeutic options show several limitations. In the search for more effective drugs, plant compounds represent a powerful natural source. Artemisinin is… read more here.
Keywords: leishmania braziliensis; mitochondrial bioenergetics; dqhs; artemisinin ... See more keywords
Virtual screening to identify Leishmania braziliensis N-myristoyltransferase inhibitors: pharmacophore models, docking, and molecular dynamics
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-018-3791-8
Abstract: Leishmaniasis is caused by several protozoa species belonging to genus Leishmania that are hosted by humans and other mammals. Millions of new cases are recorded every year and the drugs available on the market do… read more here.
Keywords: virtual screening; leishmania braziliensis; docking molecular; molecular dynamics ... See more keywords
Structural and functional studies of the Leishmania braziliensis mitochondrial Hsp70: Similarities and dissimilarities to human orthologues.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2016.11.004
Abstract: Heat shock protein 70 kDa (Hsp70) is a conserved molecular chaperone family involved in several functions related to protein homeostasis. In eukaryotes, Hsp70 homologues are found in all cell compartments. The mitochondrial Hsp70 isoform (mtHsp70) is… read more here.
Keywords: leishmania braziliensis; hsp70; human orthologues; mitochondrial hsp70 ... See more keywords
Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of New World Tegumentary Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114191
Abstract: The protozoan parasite Leishmania braziliensis is a major causative agent of the neglected tropical diseases Cutaneous and Mucocutaneous Leishmaniases in the New World. There are no vaccines to prevent the infection and the treatment relies… read more here.
Keywords: leishmania braziliensis; new world; braziliensis; causative agent ... See more keywords
Design, synthesis, structure-activity relationship and mechanism of action studies of a series of 4-chloro-1-phthalazinyl hydrazones as a potent agent against Leishmania braziliensis.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.022
Abstract: With the aim to identify a potential drug candidate to treat cutaneous leishmaniasis, a series of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis parasite, one of the main responsible of this disease in… read more here.
Keywords: leishmania braziliensis; braziliensis; phthalazinyl hydrazones; activity relationship ... See more keywords
Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase
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DOI: 10.1016/j.heliyon.2020.e03733
Abstract: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in REDOX reactions and oxidative stress defense systems. Furthermore, NAD is used as substrate by proteins that regulate essential cellular functions as DNA repair, genetic, and… read more here.
Keywords: leishmania braziliensis; nicotinamide mononucleotide; braziliensis; lbnmnat protein ... See more keywords
Performance of Leishmania braziliensis enolase protein for the serodiagnosis of canine and human visceral leishmaniosis.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2017.03.024
Abstract: In the present study, Leishmania braziliensis enolase was cloned and the recombinant protein (rEnolase) was evaluated for the serodiagnosis of canine and human visceral leishmaniosis (VL). For the canine VL diagnosis, this study examined serum… read more here.
Keywords: protein; leishmania braziliensis; visceral leishmaniosis; canine ... See more keywords
Biochemical, thermodynamic and structural studies of recombinant homotetrameric adenylosuccinate lyase from Leishmania braziliensis
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DOI: 10.1039/c7ra10526f
Abstract: Adenylosuccinate lyase (ASL) is involved in both de novo and salvage pathways of purine biosynthesis. ASL belongs to the argininosuccinate lyase/fumarase C superfamily of enzymes which share a general acid–base catalytic mechanism with β-elimination of… read more here.
Keywords: state; leishmania braziliensis; lbasl; adenylosuccinate lyase ... See more keywords
Comparative transcriptomics in Leishmania braziliensis: disclosing differential gene expression of coding and putative noncoding RNAs across developmental stages
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DOI: 10.1080/15476286.2019.1574161
Abstract: ABSTRACT Leishmaniasis is a worldwide public health problem caused by protozoan parasites of the genus Leishmania. Leishmania braziliensis is the most important species responsible for tegumentary leishmaniases in Brazil. An understanding of the molecular mechanisms… read more here.
Keywords: leishmania braziliensis; braziliensis; gene expression; noncoding rnas ... See more keywords
Different inoculum of Leishmania braziliensis concentrations influence immunopathogenesis and clinical evolution in the ear dermis hamster model of cutaneous leishmaniasis
Sign Up to like & getrecommendations! Published in 2022 at "Parasite Immunology"
DOI: 10.1111/pim.12947
Abstract: The golden hamster (Mesocricetus auratus) is commonly used as a promising model for Leishmania braziliensis infection developing skin‐ulcerated lesions. However, different protocols using high concentration of parasites inoculated in the footpad result in severe clinical… read more here.
Keywords: infection; ear dermis; immunopathogenesis clinical; model ... See more keywords
Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011230
Abstract: In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical disease, cutaneous leishmaniasis (CL). CL caused by L. braziliensis can present on a spectrum of disease severity with high rate of treatment… read more here.
Keywords: whole genome; leishmania braziliensis; skin; genetics ... See more keywords