Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13429
Abstract: Zeta‐toxin is a cognate toxin of epsilon antitoxin of prokaryotic Type II toxin‐antitoxin system (TA) and play an important role in cell death. An orthologue of bacterial‐zeta‐toxin (BzT) was identified in Leishmania donovani with similar… read more here.
Keywords: leishmania donovani; zeta toxin; toxin; cell death ... See more keywords
Recent advances in understanding Leishmania donovani infection: The importance of diverse host regulatory pathways
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1759
Abstract: Invasion of host cell by pathogens induce various intracellular signalling pathways. The host cell through the initiation of these signalling circuits desperately wants to get rid of the pathogen, whereas the pathogen tries to subvert… read more here.
Keywords: understanding leishmania; donovani infection; advances understanding; recent advances ... See more keywords
In vitro 4-Aryloxy-7-chloroquinoline derivatives are effective in mono- and combined therapy against Leishmania donovani and induce mitocondrial membrane potential disruption.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.03.023
Abstract: The present study evaluates in vitro the effect of two synthetic compounds of the 7-chloro-4-aryloxyquinoline series, QI (C17H12ClNO3) and QII (C18H15ClN4O2S), on Leishmania donovani parasites. The results obtained demonstrate that these compounds are able to… read more here.
Keywords: effect; donovani; membrane potential; leishmania donovani ... See more keywords
Lupeol and amphotericin B mediate synergistic anti-leishmanial immunomodulatory effects in Leishmania donovani-infected BALB/c mice.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155319
Abstract: Leishmania donovani, a protozoan parasite, inflicts the disease Visceral leishmaniasis (VL) Worldwide. The only orally bioavailable drug miltefosine is toxic, whereas liposomal amphotericin B (AmpB) is expensive. Lupeol, a triterpenoid from Sterculia villosa bark, was… read more here.
Keywords: leishmanial immunomodulatory; anti leishmanial; lupeol; immunomodulatory effects ... See more keywords
Glycyrrhizic acid attenuates growth of Leishmania donovani by depleting ergosterol levels
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Parasitology"
DOI: 10.1016/j.exppara.2017.02.015
Abstract: Abstract In the present study, glycyrrhizic acid (GA) the main component of Glycyrrhiza glabra was evaluated for its efficacy as antileishmanial agent and its mode of action explored. GA inhibits promastigotes and intracellular amastigotes in… read more here.
Keywords: growth; ergosterol; glycyrrhizic acid; ergosterol levels ... See more keywords
In silico studies and evaluation of antiparasitic role of a novel pyruvate phosphate dikinase inhibitor in Leishmania donovani infected macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.12.011
Abstract: The present work deals with the identification and characterization of a novel inhibitor Z220582104, specific to pyruvate phosphate dikinase, for leishmanicidal activities against free promastigotes and intracellular amastigotes. We have used structure-based drug designing approaches… read more here.
Keywords: inhibitor; phosphate dikinase; pyruvate phosphate; infected macrophages ... See more keywords
Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.02.257
Abstract: The enzyme pyridoxal kinase (PdxK) catalyzes the conversion of pyridoxal to pyridoxal-5'-phosphate using ATP as the co-factor. The product pyridoxal-5'-phosphate (PLP) plays a key role in several biological processes such as transamination, decarboxylation and deamination.… read more here.
Keywords: leishmania donovani; pyridoxal kinase; pyridoxal; ldpdxk ... See more keywords
Analysis of genetic polymorphisms and tropism in East African Leishmania donovani by Amplified Fragment Length Polymorphism and kDNA minicircle sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2018.07.016
Abstract: Visceral leishmaniasis (VL), the most severe form of leishmaniasis, is caused by Leishmania donovani. In addition to fatal VL, these parasites also cause skin diseases in immune-competent and -suppressed people, post-kala azar dermal leishmaniasis (PKDL)… read more here.
Keywords: length polymorphism; amplified fragment; analysis; fragment length ... See more keywords
Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology international"
DOI: 10.1016/j.parint.2019.02.006
Abstract: Leishmaniasis is a parasitic disease representing an important problem of public health. Visceral leishmaniasis, resulting from infection with Leishmania donovani, causes considerable mortality and morbidity in the poorest region of the word. At present there… read more here.
Keywords: intracellular ca2; leishmania donovani; ca2 homeostasis; ca2 ... See more keywords
High resolution melting based method for rapid discriminatory diagnosis of co-infecting Leptomonas seymouri in Leishmania donovani-induced leishmaniasis.
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology international"
DOI: 10.1016/j.parint.2019.102047
Abstract: Leishmania donovani, a protozoan parasite of family Trypanosomatidae, causes fatal visceral leishmaniasis (VL) in the Indian subcontinent and Africa and cutaneous leishmaniasis (CL) in Sri Lanka. Another member of Trypanosomatidae, Leptomonas seymouri, resembling Leishmania was… read more here.
Keywords: leishmaniasis; diagnosis; donovani; leishmania donovani ... See more keywords
A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34812-x
Abstract: Leishmania donovani is responsible for visceral leishmaniasis, a neglected and lethal parasitic disease with limited treatment options and no vaccine. The study of L. donovani has been hindered by the lack of a high-quality reference… read more here.
Keywords: virulence; reference genome; leishmania donovani; donovani ... See more keywords