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   Articles with "leishmania major" as a keyword



Effect of hybridization on lipophosphoglycan expression in Leishmania major

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11798

Abstract: Leishmania major is the causative agent of cutaneous leishmaniasis. It is one of the most studied Leishmania species not only during vector interaction but also in the vertebrate host. Lipophosphoglycan (LPG) is the Leishmania multifunctional… read more here.

Keywords: hybridization lipophosphoglycan; expression; leishmania; leishmania major ... See more keywords
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The effects of CCR7 and related signaling pathways on Leishmania major ‐infected human dendritic cells

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27985

Abstract: In our research, we aimed to investigate the roles of CC‐chemokine receptor 7 (CCR7) and relevant signaling pathways in Leishmania major‐infected human dendritic cells (DCs). read more here.

Keywords: signaling pathways; leishmania major; pathways leishmania; major infected ... See more keywords

Comparison of biosynthetic zinc oxide nanoparticle and glucantime cytotoxic effects on Leishmania major (MRHO/IR/75/ER)

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recommendations! Published in 2024 at "Journal of Basic Microbiology"

DOI: 10.1002/jobm.202300490

Abstract: Currently, zinc oxide (ZnO) particles are used in nanotechnology to destroy a wide range of microorganisms. Although pentavalent antimony compounds are used as antileishmanial drugs, they are associated with several limitations and side effects. Therefore,… read more here.

Keywords: zinc oxide; leishmania major; major mrho; culture ... See more keywords

The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes

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recommendations! Published in 2024 at "Journal of Biological Inorganic Chemistry"

DOI: 10.1007/s00775-024-02063-z

Abstract: Encephalitozoon intestinalis is an opportunistic microsporidian parasite that primarily infects immunocompromised individuals, such as those with HIV/AIDS or undergoing organ transplantation. Leishmaniasis is responsible for parasitic infections, particularly in developing countries. The disease has not… read more here.

Keywords: heterocyclic carbene; leishmania major; major promastigotes; encephalitozoon intestinalis ... See more keywords

An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors.

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recommendations! Published in 2017 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.03.043

Abstract: Despite the fact that Leishmania ssp are pteridine auxotrophs, Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) inhibitors are ineffective against Leishmania major. On the other hand Pteridine Reductase 1 (PTR1) inhibitors proved to be lethal to the parasite.… read more here.

Keywords: leishmania major; reductase; pteridine; non nucleoside ... See more keywords

Evaluation of protection induced by in vitro maturated BMDCs presenting CD8+ T cell stimulating peptides after a heterologous vaccination regimen in BALB/c model against Leishmania major.

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recommendations! Published in 2021 at "Experimental parasitology"

DOI: 10.1016/j.exppara.2021.108082

Abstract: Leishmaniasis is a complex vector-borne disease mediated by Leishmania parasite and a strong and long-lasting CD4+ Th1 and CD8+-T cell immunity is required to control the infection. Thus far multivalent subunit vaccines have met this… read more here.

Keywords: cd8 cell; cell; leishmania major; evaluation protection ... See more keywords
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Genomic cartography and proposal of nomenclature for the repeated, interspersed elements of the Leishmania major SIDER2 family and identification of SIDER2-containing transcripts.

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recommendations! Published in 2017 at "Molecular and biochemical parasitology"

DOI: 10.1016/j.molbiopara.2016.12.009

Abstract: The genomes of most eukaryotic organisms contain a large number of transposable elements that are able to move from one genomic site to another either by transferring of DNA mobile elements (transposons) or transpose via… read more here.

Keywords: sider2; leishmania major; cartography; genomic cartography ... See more keywords

Synchrotron-Infrared Microspectroscopy of Live Leishmania major Infected Macrophages and Isolated Promastigotes and Amastigotes.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c04004

Abstract: The prevalence of neglected tropical diseases (NTDs) is advancing at an alarming rate. The NTD leishmaniasis is now endemic in over 90 tropical and sub-tropical low socioeconomic countries. Current diagnosis for this disease involves serological… read more here.

Keywords: synchrotron infrared; infrared microspectroscopy; microscopy; leishmania major ... See more keywords

Role of Macrophage PIST Protein in Regulating Leishmania major Infection.

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recommendations! Published in 2024 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.4c00156

Abstract: PDZ protein interacting specifically with Tc10 or PIST is a mammalian trans-Golgi resident protein that regulates subcellular sorting of plasma membrane receptors. PIST has recently emerged as a key player in regulating viral pathogenesis. Nevertheless,… read more here.

Keywords: pist; leishmania major; protein; macrophage ... See more keywords

GP63 Alters the Macrophage Golgin160-Associated PIST Distribution by Reducing Caspase-3 Expression during Leishmania major Infection.

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recommendations! Published in 2025 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.5c00531

Abstract: Leishmania major, an intracellular protozoan parasite, resides within parasitophorous vacuoles in host macrophages and relies on host-pathway manipulation for survival. Here, we uncover a novel role of the Leishmania surface metalloprotease GP63 in stabilizing the… read more here.

Keywords: parasitophorous vacuoles; leishmania major; leishmania; gp63 ... See more keywords

Leishmania major cutaneous leishmaniasis outbreak in the Jordanian side of the Northern Jordan Valley

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recommendations! Published in 2018 at "Pathogens and Global Health"

DOI: 10.1080/20477724.2018.1431191

Abstract: Abstract Cutaneous leishmaniasis (CL) is endemic in many foci of Jordan and the Jordanian Mid Jordan Valley (JMJV) is the most affected and the incidence is quite high. The situation in the northern part of… read more here.

Keywords: jordanian side; leishmania major; jordan; cutaneous leishmaniasis ... See more keywords