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   Articles with "leishmania major" as a keyword



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Effect of hybridization on lipophosphoglycan expression in Leishmania major

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11798

Abstract: Leishmania major is the causative agent of cutaneous leishmaniasis. It is one of the most studied Leishmania species not only during vector interaction but also in the vertebrate host. Lipophosphoglycan (LPG) is the Leishmania multifunctional… read more here.

Keywords: hybridization lipophosphoglycan; expression; leishmania; leishmania major ... See more keywords
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The effects of CCR7 and related signaling pathways on Leishmania major ‐infected human dendritic cells

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27985

Abstract: In our research, we aimed to investigate the roles of CC‐chemokine receptor 7 (CCR7) and relevant signaling pathways in Leishmania major‐infected human dendritic cells (DCs). read more here.

Keywords: signaling pathways; leishmania major; pathways leishmania; major infected ... See more keywords
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An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors.

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recommendations! Published in 2017 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.03.043

Abstract: Despite the fact that Leishmania ssp are pteridine auxotrophs, Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) inhibitors are ineffective against Leishmania major. On the other hand Pteridine Reductase 1 (PTR1) inhibitors proved to be lethal to the parasite.… read more here.

Keywords: leishmania major; reductase; pteridine; non nucleoside ... See more keywords
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Evaluation of protection induced by in vitro maturated BMDCs presenting CD8+ T cell stimulating peptides after a heterologous vaccination regimen in BALB/c model against Leishmania major.

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recommendations! Published in 2021 at "Experimental parasitology"

DOI: 10.1016/j.exppara.2021.108082

Abstract: Leishmaniasis is a complex vector-borne disease mediated by Leishmania parasite and a strong and long-lasting CD4+ Th1 and CD8+-T cell immunity is required to control the infection. Thus far multivalent subunit vaccines have met this… read more here.

Keywords: cd8 cell; cell; leishmania major; evaluation protection ... See more keywords
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Genomic cartography and proposal of nomenclature for the repeated, interspersed elements of the Leishmania major SIDER2 family and identification of SIDER2-containing transcripts.

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recommendations! Published in 2017 at "Molecular and biochemical parasitology"

DOI: 10.1016/j.molbiopara.2016.12.009

Abstract: The genomes of most eukaryotic organisms contain a large number of transposable elements that are able to move from one genomic site to another either by transferring of DNA mobile elements (transposons) or transpose via… read more here.

Keywords: sider2; leishmania major; cartography; genomic cartography ... See more keywords
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Synchrotron-Infrared Microspectroscopy of Live Leishmania major Infected Macrophages and Isolated Promastigotes and Amastigotes.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c04004

Abstract: The prevalence of neglected tropical diseases (NTDs) is advancing at an alarming rate. The NTD leishmaniasis is now endemic in over 90 tropical and sub-tropical low socioeconomic countries. Current diagnosis for this disease involves serological… read more here.

Keywords: synchrotron infrared; infrared microspectroscopy; microscopy; leishmania major ... See more keywords
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Leishmania major cutaneous leishmaniasis outbreak in the Jordanian side of the Northern Jordan Valley

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recommendations! Published in 2018 at "Pathogens and Global Health"

DOI: 10.1080/20477724.2018.1431191

Abstract: Abstract Cutaneous leishmaniasis (CL) is endemic in many foci of Jordan and the Jordanian Mid Jordan Valley (JMJV) is the most affected and the incidence is quite high. The situation in the northern part of… read more here.

Keywords: jordanian side; leishmania major; jordan; cutaneous leishmaniasis ... See more keywords
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The Potential Role of Humans in the Transmission Cycle of Leishmania major (Kinetoplastida: Trypanosomatidae), the Causative Agent of the Old World Zoonotic Cutaneous Leishmaniasis

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recommendations! Published in 2018 at "Journal of Medical Entomology"

DOI: 10.1093/jme/tjy110

Abstract: Abstract Zoonotic cutaneous leishmaniasis (ZCL) due to Leishmania major (Yakimoff and Schokhor, 1914) (Kinetoplastida: Trypanosomatidae) is known as a neglected tropical disease, transmitted by Phlebotomus papatasi (Scopoli, 1786) (Diptera: Psychodidae) in North Africa and the… read more here.

Keywords: sand; leishmania major; sand flies; zoonotic cutaneous ... See more keywords
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In silico prediction of Leishmania major‐specific CD8+ epitopes

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recommendations! Published in 2017 at "Experimental Dermatology"

DOI: 10.1111/exd.13295

Abstract: Infections with Leishmania (L.) major induce protective IFN‐γ‐dependent Th1/Tc1 immunity in C57BL/6 mice as well as in immunocompetent humans. Even though antigen‐specific immunity provides lifelong immunity against reinfection, a vaccine against this pathogen does not… read more here.

Keywords: leishmania major; cd8; prediction leishmania; silico prediction ... See more keywords
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Leishmania major adenylate kinase immunization offers partial protection to a susceptible host

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recommendations! Published in 2019 at "Parasite Immunology"

DOI: 10.1111/pim.12688

Abstract: Leishmania major causes mild‐to‐severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug‐resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we… read more here.

Keywords: protection; immunization; leishmania major; major adenylate ... See more keywords
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Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection

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recommendations! Published in 2018 at "Mediators of Inflammation"

DOI: 10.1155/2018/9787128

Abstract: Certain cytokines modulate the expression of insulin-like growth factor- (IGF-) I. Since IL-4 and IGF-I promote growth of the protozoan Leishmania major, we here addressed their interaction in downregulating the expression of Igf-I mRNA using… read more here.

Keywords: leishmania major; infection; insulin like; igf ... See more keywords