In vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-021-07266-w
Abstract: The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main Leishmania species that cause cutaneous leishmaniasis in Venezuela. Final compounds 4-7 were generated… read more here.
Keywords: braziliensis; nitroimidazole sulfanyl; evaluation; leishmania mexicana ... See more keywords
Immunosuppression by UVB radiation exacerbates Leishmania mexicana skin lesions in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta tropica"
DOI: 10.1016/j.actatropica.2021.106041
Abstract: Cutaneous leishmaniasis is the most common form of leishmaniasis in humans. The disease is caused by several species, such as Leishmania mexicana, a protozoa parasite. Several major risk factors are associated with this disease, including… read more here.
Keywords: skin lesions; leishmaniasis; cutaneous leishmaniasis; leishmania mexicana ... See more keywords
Leishmania mexicana cell death achieved by Cleoserrata serrata (Jacq.) Iltis: Learning from Maya healers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.09.037
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Aerial parts of Cleoserrata serrata (Jacq.) Iltis are widely used in South-Central Mexico to treat wounds and bacterial skin infections and in Panama by Kuna, Ngöbe-Buglé, and Teribe Indians for tropical warm baths… read more here.
Keywords: cleoserrata serrata; mexicana; serrata jacq; jacq iltis ... See more keywords
Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010779
Abstract: Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin.… read more here.
Keywords: leishmania mexicana; oxidative stress; amphotericin; resistance ... See more keywords
Efficacy of imiquimod 5% cream as first-line management in cutaneous leishmaniasis caused by Leishmania mexicana
Sign Up to like & getrecommendations! Published in 2021 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0305-2020
Abstract: Abstract Cutaneous leishmaniasis (CL) involves several differential diagnoses as it lacks a gold standard diagnostic test. Its diagnosis is easier in endemic regions; however, many cases come from travelers to endemic areas. A 22-year-old patient,… read more here.
Keywords: imiquimod cream; cutaneous leishmaniasis; leishmania mexicana; mexicana ... See more keywords
Evaluation of the Anti-Leishmania mexicana and -Trypanosoma brucei Activity and Mode of Action of 4,4′-(Arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081913
Abstract: Trypanosomiasis and leishmaniasis are neglected infections caused by trypanosomatid parasites. The first-line treatments have many adverse effects, high costs, and are prone to resistance development, hence the necessity for new chemotherapeutic options. In line with… read more here.
Keywords: brucei; trypanosoma brucei; leishmania mexicana; mexicana trypanosoma ... See more keywords
Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24061024
Abstract: New anti-infective agents are urgently needed to fight microbial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) strains are particularly responsible for complicated pathologies that are difficult to treat due to their virulence and the formation of persistent… read more here.
Keywords: staphylococcus aureus; resistant staphylococcus; trypanosoma brucei; methicillin resistant ... See more keywords
Virtual Screening of Benzimidazole Derivatives as Potential Triose Phosphate Isomerase Inhibitors with Biological Activity against Leishmania mexicana
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030390
Abstract: Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), a “Neglected disease”, for which the search for new drugs is a priority. Benzimidazole is a scaffold used to develop antiparasitic drugs; therefore,… read more here.
Keywords: virtual screening; leishmania mexicana; isomerase; benzimidazole ... See more keywords
Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes
Sign Up to like & getrecommendations! Published in 2023 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed8020115
Abstract: Malachra alceifolia Jacq. (family Malvaceae), known as “malva,” is a medicinal plant used as a traditional therapy in many regions of America, Africa and Asia. Traditionally, this plant is used in the form of extracts,… read more here.
Keywords: malachra alceifolia; leishmania mexicana; mexicana amastigotes; activity ... See more keywords