Expression, Purification, and Evaluation of Anti-IL-2Rα Antibody Secreted by Leishmania tarentolae
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10088-6
Abstract: Producing a functional anti-IL-2R α antibody in Leishmania tarentolae , a trypanosomatid protozoan non-pathogenic to human, is a cost-effective and safe alternative for the production of therapeutic recombinant proteins. Expression cassettes encoding heavy and light… read more here.
Keywords: leishmania tarentolae; anti antibody; purification evaluation; antibody ... See more keywords
Testing the CRISPR-Cas9 and glmS ribozyme systems in Leishmania tarentolae.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2020.111336
Abstract: Leishmania parasites include important pathogens and model organisms and are even used for the production of recombinant proteins. However, functional genomics and the characterization of essential genes are often limited in Leishmania because of low-throughput… read more here.
Keywords: knock; glms ribozyme; leishmania tarentolae; crispr cas9 ... See more keywords
Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases
Sign Up to like & getrecommendations! Published in 2022 at "Transboundary and Emerging Diseases"
DOI: 10.1111/tbed.14660
Abstract: Abstract Leishmaniasis (or the leishmaniases), classified as a neglected tropical parasitic disease, is found in parts of the tropics, subtropics and southern Europe. Leishmania parasites are transmitted by the bite of phlebotomine sand flies and… read more here.
Keywords: tarentolae new; leishmania tarentolae; frontier epidemiology; new frontier ... See more keywords
Leishmania tarentolae: Taxonomic classification and its application as a promising biotechnological expression host
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007424
Abstract: In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications. We will also discuss the genus, subgenus, and species-level classification… read more here.
Keywords: tarentolae; leishmania tarentolae; expression; expression host ... See more keywords
Saurian-associated Leishmania tarentolae in dogs: Infectivity and immunogenicity evaluation in the canine model
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1012598
Abstract: In canine leishmaniosis endemic areas, Leishmania infantum may occur in sympatry with the non-pathogenic Leishmania tarentolae, which is associated to reptiles. The potential infectivity of L. tarentolae for mammals raises questions about the interactions between… read more here.
Keywords: tarentolae; canine; leishmania tarentolae; infectivity ... See more keywords
Live Leishmania tarentolae secreting HNP1 as an immunotherapeutic tool against Leishmania infection in BALB/c mice.
Sign Up to like & getrecommendations! Published in 2017 at "Immunotherapy"
DOI: 10.2217/imt-2017-0076
Abstract: AIM Several disadvantages about chemotherapy for leishmaniasis has reinforced discovery of novel therapeutic agents especially immunotherapeutics. HNP1, as a member of the mammalian antimicrobial peptides family, is an attractive molecule due to its broad functional… read more here.
Keywords: leishmania tarentolae; tool leishmania; infection; balb mice ... See more keywords
The non-pathogenic protozoon Leishmania tarentolae interferes with the activation of NLRP3 inflammasome in human cells: new perspectives in the control of inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1298275
Abstract: Background Innate immune responses against infectious agents can act as triggers of inflammatory diseases. On the other hand, various pathogens have developed mechanisms for the evasion of the immune response, based on an inhibition of… read more here.
Keywords: inflammatory; leishmania; nlrp3 inflammasome; leishmania tarentolae ... See more keywords
Potent Inhibitory Activity of Natural Product Anaephene B and Analogues against Leishmania tarentolae In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28030946
Abstract: In this study, a specific alkylphenol natural product, anaephene B, and its unique synthesized derivatives were tested for their inhibitory effect on the protozoan parasite Leishmania tarentolae. In a series of cell viability tests and… read more here.
Keywords: tarentolae vitro; leishmania tarentolae; anaephene analogues; product anaephene ... See more keywords