Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil
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DOI: 10.1007/s00436-017-5403-4
Abstract: American cutaneous leishmaniasis (ACL) is a chronic infectious disease caused by different protozoan species of Leishmania, and it is endemic in both tropical and subtropical countries. Using immunohistochemistry, we investigate the density of CD68+, lysozyme+,… read more here.
Keywords: leishmania viannia; caused leishmania; density; viannia spp ... See more keywords
Genetic variant strains of Leishmania (Viannia) braziliensis exhibit distinct biological behaviors
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DOI: 10.1007/s00436-018-6014-4
Abstract: A variety of clinical forms of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis, as well as differing immune responses of patients, have been reported for an ACL focus in the state of Minas Gerais,… read more here.
Keywords: strains leishmania; variant strains; leishmania viannia; braziliensis ... See more keywords
Leishmania (Viannia) guyanensis in tegumentary leishmaniasis
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DOI: 10.1093/femspd/fty025
Abstract: Abstract Leishmania (Viannia) guyanensis is a causal agent of American tegumentary leishmaniasis (ATL). This protozoan has been poorly investigated; however, it can cause different clinical forms of ATL, ranging from a single cutaneous lesion to… read more here.
Keywords: tegumentary leishmaniasis; guyanensis; leishmania viannia; viannia guyanensis ... See more keywords
Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection
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DOI: 10.1128/iai.00981-16
Abstract: ABSTRACT Infection by Leishmania (Viannia) panamensis, the predominant etiologic agent for cutaneous leishmaniasis in Colombia, is characterized by a chronic mixed inflammatory response. Current treatment options are plagued by toxicity, lengthy treatment regimens, and growing… read more here.
Keywords: leishmania viannia; response; treatment; infection ... See more keywords
Natural infections of Pintomyia verrucarum and Pintomyia maranonensis by Leishmania (Viannia) peruviana in the Eastern Andes of northern Peru
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DOI: 10.1371/journal.pntd.0009352
Abstract: The natural infection of sand flies by Leishmania was investigated in Andean areas located between the Central and Eastern Cordilleras of northern Peru where cutaneous leishmaniasis caused by Leishmania (Viannia) peruviana is endemic. Sand flies… read more here.
Keywords: leishmania viannia; peruviana; maranonensis; sand flies ... See more keywords
Genetic diversity and population structure of Leishmania (Viannia) braziliensis in the Peruvian jungle
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DOI: 10.1371/journal.pntd.0010374
Abstract: Background Human cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis is highly prevalent in the Peruvian jungle, where it affects military forces deployed to fight against drug trafficking and civilian people that migrate from the highland… read more here.
Keywords: genetic diversity; braziliensis; jungle; leishmania viannia ... See more keywords
High levels of infectiousness of asymptomatic Leishmania (Viannia) braziliensis infections in wild rodents highlights their importance in the epidemiology of American Tegumentary Leishmaniasis in Brazil
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DOI: 10.1371/journal.pntd.0010996
Abstract: Background The epidemiological significance of wildlife infections with aetiological agents causing human infectious diseases is largely determined by their infection status, contact potential with humans (via vectors for vector-borne diseases), and their infectiousness to maintain… read more here.
Keywords: tegumentary leishmaniasis; rodent species; braziliensis; leishmania viannia ... See more keywords
Detection of Leishmania RNA Virus 1 in Leishmania (Viannia) panamensis Isolates, Panama
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DOI: 10.3201/eid2906.220012
Abstract: We detected Leishmania RNA virus 1 (LRV1) in 11 isolates of Leishmania (Viannia) panamensis collected during 2014–2019 from patients from different geographic areas in Panama. The distribution suggested a spread of LRV1 in L. (V.)… read more here.
Keywords: leishmania rna; viannia panamensis; panamensis; leishmania ... See more keywords
A New Target Organ of Leishmania (Viannia) braziliensis Chronic Infection: The Intestine
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DOI: 10.3389/fcimb.2021.687499
Abstract: Leishmania (Viannia) braziliensis is one of the main causes of cutaneous leishmaniasis in the Americas. This species presents genetic polymorphism that can cause destructive lesions in oral, nasal, and oropharyngeal tracts. In a previous study,… read more here.
Keywords: leishmania viannia; braziliensis; infection; target organ ... See more keywords
Effective Genome Editing in Leishmania (Viannia) braziliensis Stably Expressing Cas9 and T7 RNA Polymerase
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DOI: 10.3389/fcimb.2021.772311
Abstract: Until 2015, loss-of-function studies to elucidate protein function in Leishmania relied on gene disruption through homologous recombination. Then, the CRISPR/Cas9 revolution reached these protozoan parasites allowing efficient genome editing with one round of transfection. In… read more here.
Keywords: cas9; leishmania viannia; genome editing; braziliensis ... See more keywords
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis
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DOI: 10.3389/fcimb.2022.1059168
Abstract: Leishmaniasis is a parasitic disease caused by several species of intracellular protozoa of the genus Leishmania that present manifestations ranging from cutaneous ulcers to the fatal visceral form. Leishmania Viannia braziliensis is an important species… read more here.
Keywords: hamsters infected; viannia braziliensis; quercetin; braziliensis ... See more keywords