In vitro leishmanicidal activity and theoretical insights into biological action of ruthenium(II) organometallic complexes containing anti-inflammatories
Sign Up to like & getrecommendations! Published in 2018 at "BioMetals"
DOI: 10.1007/s10534-018-0145-z
Abstract: Leishmaniasis, a neglected tropical disease caused by protozoans of the genus Leishmania, kills around 20–30 thousand people in Africa, Asia, and Latin America annually and, despite its potential lethality, it can be treated and eventually… read more here.
Keywords: ruthenium organometallic; organometallic complexes; complexes containing; leishmanicidal activity ... See more keywords
Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2019.04.003
Abstract: In the present study, we investigated the in vitro and in vivo leishmanicidal activity of synthetic compounds, containing a semicarbazone scaffold as a peptide mimetic framework. The leishmanicidal effect against amastigotes of Leishmania amazonensis was… read more here.
Keywords: amazonensis; semicarbazone derivatives; leishmanicidal activity; activity ... See more keywords
Synthesis and in vitro leishmanicidal activity of novel [1,2,3]triazolo[1,5-a]pyridine salts
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DOI: 10.1039/c7ra01070b
Abstract: Leishmaniasis remains a significant worldwide problem; it is of great interest to develop new drugs to fight this disease. Recently we described some [1,2,3]triazolo[1,5-a]pyridine compounds with significant leishmanicidal activity. The importance of water solubility in… read more here.
Keywords: vitro leishmanicidal; triazolo pyridine; novel triazolo; leishmanicidal activity ... See more keywords
Increased in vitro leishmanicidal activity of octyl gallate loaded poly(methyl methacrylate) nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2018.1547747
Abstract: Abstract The current paucity of effective and affordable drugs for the treatment of leishmaniasis renders the search for new therapeutic alternatives a priority. Gallic acid-related compounds display anti-parasitic activities and their incorporation into drug carrier… read more here.
Keywords: leishmanicidal activity; loaded poly; gallate loaded; pmma nanoparticles ... See more keywords