Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis
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DOI: 10.1038/s41421-021-00259-0
Abstract: Pannexin1 (PANX1) is a large-pore ATP efflux channel with a broad distribution, which allows the exchange of molecules and ions smaller than 1 kDa between the cytoplasm and extracellular space. In this study, we show that… read more here.
Keywords: full length; pyroptosis; channel; pannexin1 ... See more keywords
X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31997-z
Abstract: RuvB-Like transcription factors function in cell cycle regulation, development and human disease, such as cancer and heart hyperplasia. The mechanisms that regulate adenosine triphosphate (ATP)-dependent activity, oligomerization and post-translational modifications in this family of enzymes… read more here.
Keywords: structure full; full length; ruvb like; atp binding ... See more keywords
Structural Characterization of Full-Length Human Dehydrodolichyl Diphosphate Synthase Using an Integrative Computational and Experimental Approach
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DOI: 10.3390/biom9110660
Abstract: Dehydrodolichyl diphosphate synthase (DHDDS) is the catalytic subunit of the heteromeric human cis-prenyltransferase complex, synthesizing the glycosyl carrier precursor for N-linked protein glycosylation. Consistent with the important role of N-glycosylation in protein biogenesis, DHDDS mutations… read more here.
Keywords: length; dehydrodolichyl diphosphate; full length; diphosphate synthase ... See more keywords
Role of telomere length in human carcinogenesis (Review).
Sign Up to like & getrecommendations! Published in 2023 at "International journal of oncology"
DOI: 10.3892/ijo.2023.5526
Abstract: Cancer is considered the most important clinical, social and economic issue regarding cause‑specific disability‑adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific… read more here.
Keywords: telomere length; role telomere; review; carcinogenesis ... See more keywords