Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas
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DOI: 10.1002/cncr.31754
Abstract: Uterine leiomyomas (ULs) are the most common gynecologic tumors and affect 3 of every 4 women by the age of 50 years. The majority of ULs are classified as conventional tumors, whereas 10% represent various… read more here.
Keywords: uterine leiomyomas; daxx expression; alternative lengthening; lengthening telomeres ... See more keywords
Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
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DOI: 10.1016/j.celrep.2020.107983
Abstract: Summary The Tousled-like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1 histone chaperone and influence cell cycle progression and genome maintenance, yet the mechanisms underlying TLK-mediated genome stability remain uncertain. Here, we… read more here.
Keywords: kinases suppress; alternative lengthening; like kinases; innate immune ... See more keywords
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway.
Sign Up to like & getrecommendations! Published in 2021 at "DNA repair"
DOI: 10.1016/j.dnarep.2021.103055
Abstract: The maintenance of telomeres, which are specialized stretches of DNA found at the ends of linear chromosomes, is a crucial step for the immortalization of cancer cells. Approximately 10-15 % of cancer cells use a… read more here.
Keywords: dna; alternative lengthening; replication stress; replication ... See more keywords
ALT-FISH quantifies alternative lengthening of telomeres activity by imaging of single-stranded repeats
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DOI: 10.1093/nar/gkac113
Abstract: Abstract Alternative lengthening of telomeres (ALT) occurs in ∼10% of cancer entities. However, little is known about the heterogeneity of ALT activity since robust ALT detection assays with high-throughput in situ readouts are lacking. Here,… read more here.
Keywords: single stranded; lengthening telomeres; alt fish; activity ... See more keywords
Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands
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DOI: 10.1093/nar/gkw1295
Abstract: Abstract Alternative lengthening of telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in ∼15% of cancers. The potential mechanism of ALT is homology-directed telomere synthesis, but molecular mechanisms of how ALT maintains… read more here.
Keywords: alternative lengthening; telomerase positive; elongation; preferential elongation ... See more keywords
Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers
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DOI: 10.1098/rsob.220011
Abstract: Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate. Structural aberrations that promote activation… read more here.
Keywords: alternative lengthening; replication; replication stress; lengthening telomeres ... See more keywords
Prevalence and potentially prognostic value of C‐circles associated with alternative lengthening of telomeres in canine appendicular osteosarcoma
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DOI: 10.1111/vco.12665
Abstract: Abstract Alternative lengthening of telomeres (ALT) is a telomerase‐independent telomere maintenance mechanism (TMM) with high prevalence in human osteosarcomas but remains unknown in canine osteosarcomas. The aim of this study was to evaluate the prevalence… read more here.
Keywords: alternative lengthening; prevalence; appendicular osteosarcoma; osteosarcomas ... See more keywords
Abstract 1466: DAXX localizes ATRX to suppress alternative lengthening of telomeres in osteosarcoma
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DOI: 10.1158/1538-7445.am2018-1466
Abstract: To maintain genome stability, proliferating cells must add telomere sequence to counteract the chromosome end replication problem. In normal cells, telomeres are lengthened through the action of the enzyme telomerase. In about 10-15% of tumors,… read more here.
Keywords: daxx localizes; daxx; alternative lengthening; localizes atrx ... See more keywords
Abstract 2628: Synthetic lethal targeting of ATR in alternative lengthening of telomeres-dependent rhabdomyosarcoma
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DOI: 10.1158/1538-7445.am2018-2628
Abstract: Synthetic lethal dependencies have recently emerged as tumor-specific vulnerabilities which provide broad therapeutic windows and have successfully been used for rational therapeutic target discovery. Despite intense international efforts over many decades, cure rates for patients… read more here.
Keywords: dependent rhabdomyosarcoma; alternative lengthening; rhabdomyosarcoma; lengthening telomeres ... See more keywords
Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4924
Abstract: Glioblastoma (GBM), the most common primary malignant brain tumor in adults, is an incurable disease that has an inevitable tendency to recur following standard of care surgery, radiotherapy, and temozolomide chemotherapy. There is an urgent… read more here.
Keywords: glioblastoma; lengthening telomeres; topoisomerase; gbm ... See more keywords
Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies
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DOI: 10.3389/fonc.2019.01518
Abstract: Achieving replicative immortality is a crucial step in tumorigenesis and requires both bypassing cell cycle checkpoints and the extension of telomeres, sequences that protect the distal ends of chromosomes during replication. In the majority of… read more here.
Keywords: alternative lengthening; telomeres pediatric; mechanisms therapies; pediatric cancer ... See more keywords