Down-regulation of GJA3 is associated with lens epithelial cell apoptosis and age-related cataract.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.050
Abstract: Lens epithelial cell apoptosis is regarded as the common molecular basis of the initiation and subsequent progression of cataract. Recent studies have shown that Oxidative radicals derived from H2O2 causes lens epithelial cell apoptosis, While… read more here.
Keywords: gja3; epithelial cell; lens epithelial; apoptosis ... See more keywords
The core structure of a Dendrobium huoshanense polysaccharide required for the inhibition of human lens epithelial cell apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2016.08.087
Abstract: The aim of this work was to investigate the core structure of a Dendrobium huoshanense polysaccharide DHPD1 required for the inhibition of lens epithelial cell apoptosis. In order to obtain the fragments containing the core… read more here.
Keywords: lens epithelial; apoptosis; cell apoptosis; core structure ... See more keywords
Capsella bursa-pastoris (L.) Medic. extract alleviate cataract development by regulating the mitochondrial apoptotic pathway of the lens epithelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114783
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Capsella bursa-pastoris (L.) Medic. (CBP) is a cruciferous plant valuable in reducing fever, improving eyesight and calming the liver. This herb was recorded in the Compendium of Materia Medica for cataract treatment. AIM… read more here.
Keywords: epithelial cells; lens epithelial; mitochondrial apoptotic; cataract ... See more keywords
Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07619-5
Abstract: Transforming growth factor β (TGFβ) and fibroblast growth factor (FGF) signaling pathways play important roles in the proliferation and differentiation of lens epithelial cells (LECs) during development. Low dosage bFGF promotes cell proliferation while high… read more here.
Keywords: lens epithelial; proliferation; differentiation; vitro ... See more keywords
GJA8 missense mutation disrupts hemichannels and induces cell apoptosis in human lens epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55549-1
Abstract: Autosomal dominant congenital cataract (ADCC), the most common hereditary disease, is a major cause of eye disease in children. Due to its high genetic and clinical heterogeneity, the identification of ADCC-associated gene mutations is essential… read more here.
Keywords: mutation; mutation disrupts; epithelial cells; lens epithelial ... See more keywords
CircPAG1 inhibits the high glucose-induced lens epithelial cell injury by sponging miR-630 and upregulating EPHA2.
Sign Up to like & getrecommendations! Published in 2021 at "Current eye research"
DOI: 10.1080/02713683.2021.1933058
Abstract: BACKGROUND : Circular RNAs (circRNAs) have been considered as vital regulators in the progression of human ocular diseases, including diabetic cataract (DC). This report was designed to research the biological role of circRNA phosphoprotein associated… read more here.
Keywords: cell injury; lens epithelial; circpag1; epha2 ... See more keywords
Effects of Dexamethasone on DNA Synthesis in Lens Epithelial Cells Are Dependent on Cell Type and Growth Factor
Sign Up to like & getrecommendations! Published in 2022 at "Current Eye Research"
DOI: 10.1080/02713683.2022.2052106
Abstract: Abstract Purpose To determine the factors that influence the ability of dexamethasone (dex) to inhibit or stimulate the growth of lens epithelial cells. Method Different growth factors with or without dex (10−6 M) were added… read more here.
Keywords: growth; lens epithelial; dex; growth factor ... See more keywords
Ketamine delays progression of oxidative and damaged cataract through regulating HMGB-1/NF-κB in lens epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2018.1478851
Abstract: Abstract Objective: Lens epithelial cell (LEC) membrane damage is one of the pathogenesis of cataract. High mobility group box-1 (HMGB-1) and nuclear factor-κB (NF-κB) play vital roles in a variety of diseases, such as inflammation.… read more here.
Keywords: lens epithelial; group; model group; cataract ... See more keywords
Apoptosis of Lens Epithelial Cells and Expression of NLRP3-related Proteins in Patients with Diabetes and Cataract.
Sign Up to like & getrecommendations! Published in 2022 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2022.2079537
Abstract: AIM To compare the expression of apoptosis-related factors and Nlrp3-related proteins in the lens epithelial cells (LECs) of patients with diabetes and cataract and patients with age-related cataract (ARC) alone. METHODS All patients were divided… read more here.
Keywords: apoptosis; related proteins; lens epithelial; expression ... See more keywords
Epigallocatechin gallate protects the human lens epithelial cell survival against UVB irradiation through AIF/endo G signalling pathways in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2021.1879112
Abstract: Abstract Objective Oxidative stress has been recognised as an important mediator of apoptosis in lens epithelial cells. It also plays an important role in the pathogenesis of cataracts. It is reported that (-)-Epigallocatechin gallate (EGCG),… read more here.
Keywords: aif endo; lens epithelial; apoptosis; uvb irradiation ... See more keywords
Paeoniflorin inhibits epithelial mesenchymal transformation and oxidative damage of lens epithelial cells in diabetic cataract via sirtuin 1 upregulation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018534
Abstract: ABSTRACT Paeoniflorin (Pae) has been reported to serve an important role in complications associated with diabetes. To the best of our knowledge, the role of Pae in diabetic cataracts has not yet been reported. Human… read more here.
Keywords: sra01 cells; damage; lens epithelial; oxidative damage ... See more keywords