Rapid isolation of lentivirus particles from cell culture media via a hydrophobic interaction chromatography method on a polyester, capillary-channeled polymer fiber stationary phase
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03232-8
Abstract: Lentiviruses are increasingly used as gene delivery vehicles for vaccines and immunotherapies. However, the purification of clinical-grade lentivirus vectors for therapeutic use is still troublesome and limits preclinical and clinical experiments. Current purification methods such… read more here.
Keywords: chromatography; method; lentivirus; culture media ... See more keywords
Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model
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DOI: 10.1042/bsr20193667
Abstract: Abstract We aimed to investigate the regulatory mechanism of lentivirus-mediated overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) in oxidative stress injury and inflammatory response in the lung tissue of mouse model of chronic obstructive… read more here.
Keywords: mouse model; overexpression; lentivirus; model ... See more keywords
An endogenous lentivirus in the germline of a rodent
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DOI: 10.1101/2022.09.01.506243
Abstract: Lentiviruses (genus Lentivirus ) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline. However, a small number… read more here.
Keywords: lentivirus; endogenous lentivirus; germline rodent; lentivirus germline ... See more keywords
Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3&bgr;/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia
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DOI: 10.1161/circresaha.117.310619
Abstract: Rationale: Endothelial progenitor cells (EPCs) respond to stromal cell–derived factor 1 (SDF-1) through chemokine receptors CXCR7 and CXCR4. Whether SDF-1 receptors involves in diabetes mellitus–induced EPCs dysfunction remains unknown. Objective: To determine the role of… read more here.
Keywords: kinase; epcs transduced; lentivirus; epcs ... See more keywords
Optimization of SARS-CoV-2 Pseudovirion Production in Lentivirus Backbone With a Novel Liposomal System
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.840727
Abstract: Due to the fast mutating nature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the development of novel therapeutics, vaccines, and evaluating the efficacies of existing one’s against the mutated strains is critical for containing… read more here.
Keywords: novel; system; cov pseudovirion; lentivirus ... See more keywords