Design of a CFD-DEM-based method for mechanical stress calculation and its application to glass bead-enhanced cultivations of filamentous Lentzea aerocolonigenes
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2019.04.014
Abstract: Abstract The production of chemical and pharmaceutical substances by filamentous microorganisms is a wide and challenging field of study. The morphology of filamentous microorganisms, which can vary between loose mycelia and dense pellets, is influenced… read more here.
Keywords: glass bead; stress; mechanical stress; lentzea aerocolonigenes ... See more keywords
Morphology engineering for novel antibiotics: Effect of glass microparticles and soy lecithin on rebeccamycin production and cellular morphology of filamentous actinomycete Lentzea aerocolonigenes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1171055
Abstract: Lentzea aerocolonigenes, as an actinomycete, is a natural producer of the antibiotic and antitumoral drug rebeccamycin. Due to the filamentous cellular morphology handling in cultivations is challenging; therefore, morphology engineering techniques are mandatory to enhance… read more here.
Keywords: morphology; morphology engineering; lentzea aerocolonigenes; glass microparticles ... See more keywords