Leonurine protects against dexamethasone-induced cytotoxicity in pancreatic β-cells via PI3K/Akt signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.184
Abstract: Glucocorticoid excess induces pancreatic β-cell apoptosis and insulin secretion impairment, which may lead to hyperglycemia and steroid diabetes. Leonurine is a natural alkaloid extracted from the Herba leonuri, which has been widely used in the… read more here.
Keywords: dexamethasone induced; pancreatic cells; induced cytotoxicity; dexamethasone ... See more keywords
Leonurine improves in vitro porcine embryo development competence by reducing reactive oxygen species production and protecting mitochondrial function.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.06.038
Abstract: Leonurine (LEO) is pseudoalkaloid that has been isolated from motherwort. It has been found to have various biological activities, including an antioxidant capacity. This study aimed to confirm whether LEO could be used in porcine… read more here.
Keywords: reactive oxygen; oxygen species; mitochondrial function; embryo development ... See more keywords
Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Rheumatology"
DOI: 10.1093/rheumatology/kex142
Abstract: Objective To explore the role of leonurine in the regulation of synovial inflammation and joint destruction inRA. Methods Fibroblast-like synoviocytes were isolated from synovial tissue from RA patients. Pro-inflammatory cytokine and MMP expression was evaluated… read more here.
Keywords: inflammation joint; synovial inflammation; joint destruction; leonurine ... See more keywords
Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Neural Plasticity"
DOI: 10.1155/2023/1455634
Abstract: Depression is a highly prevalent and heterogeneous disorder that requires new strategies to overcome depression. In this study, we aimed to investigate whether leonurine modulated hippocampal nerve regeneration in chronic and unpredictable mild stress (CUMS)… read more here.
Keywords: microbiota microbial; leonurine; shh gli; gut microbiota ... See more keywords
Leonurine Alleviates Cognitive Dysfunction and Reduces Oxidative Stress by Activating Nrf-2 Pathway in Alzheimer’s Disease Mouse Model
Sign Up to like & getrecommendations! Published in 2023 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s404798
Abstract: Introduction Alzheimer’s disease (AD) is the most common type of dementia, impacting approximately 50 million individuals globally. However, the current treatments available for AD are only symptomatic and have limited efficacy. This study aimed to… read more here.
Keywords: alzheimer disease; oxidative stress; model; leonurine ... See more keywords
Leonurine Promotes the Osteoblast Differentiation of Rat BMSCs by Activation of Autophagy via the PI3K/Akt/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.615191
Abstract: Background Leonurine, a major bioactive component from Herba leonuri, has been shown to exhibit anti-inflammatory and antioxidant effects. The aim of this study was to investigate the effect of leonurine on bone marrow-derived mesenchymal stem… read more here.
Keywords: mtor pathway; pi3k akt; differentiation; akt mtor ... See more keywords
Natural products in drug discovery and development: Synthesis and medicinal perspective of leonurine
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1036329
Abstract: Natural products, those molecules derived from nature, have been used by humans for thousands of years to treat ailments and diseases. More recently, these compounds have inspired chemists to use natural products as structural templates… read more here.
Keywords: discovery development; leonurine; natural products; development ... See more keywords