LEP and LEPR are possibly a double‐edged sword for wound healing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30936
Abstract: Wound healing is a complex and error‐prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form… read more here.
Keywords: lep leprs; wound healing; lep; lep lepr ... See more keywords
Provider–patient Language Discordance and Cancer Operations: Outcomes from a Single Center Linked to a State Vital Statistics Registry
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgery"
DOI: 10.1007/s00268-020-05614-y
Abstract: Patterns of worldwide immigration have resulted in high rates of discordance between medical providers and the patients they treat. For example, in the USA, 25 million individuals in the USA self-identified that they speak English… read more here.
Keywords: difference; cancer operations; center; lep ... See more keywords
Supply and Demand: Association Between Non-English Language–Speaking First Year Resident Physicians and Areas of Need in the USA
Sign Up to like & getrecommendations! Published in 2020 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-020-05935-7
Abstract: Over 25 million US inhabitants are limited English proficient (LEP). It is unknown whether physicians fluent in non-English languages are training in geographic areas with the highest proportion of LEP people. Diversity of language ability… read more here.
Keywords: resident physicians; language speaking; english language; non english ... See more keywords
The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.03.003
Abstract: Biological roles for most long non-coding RNAs (lncRNAs) remain mysterious. Here, using forward genetics, we identify lep-5, a lncRNA acting in the C. elegans heterochronic (developmental timing) pathway. Loss of lep-5 delays hypodermal maturation and male… read more here.
Keywords: lin; long non; adult transition; lep ... See more keywords
Association analysis of polymorphisms in LEP (rs7799039 and rs2167270) and LEPR (rs1137101) gene towards the development of type 2 diabetes in North Indian Punjabi population.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144846
Abstract: OBJECTIVES Obesity is a major risk factor in aetiology of type 2 diabetes mellitus (T2DM). Leptin (LEP) is an anti-obesity hormone which regulates food intake, energy expenditure and glucose metabolism. The genetic variants in leptin… read more here.
Keywords: lepr; rs1137101; type diabetes; lep ... See more keywords
Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2019.577090
Abstract: Leptin (LEP) may contribute to the pathogenesis of multiple sclerosis (MS) by its immunomodulatory, proinflammatory and prooxidant effects. Therefore, plasma LEP levels and mRNA expression of five genes related to the LEP signaling pathway (LEP,… read more here.
Keywords: lepr pgc1a; relapsing remitting; pgc1a; multiple sclerosis ... See more keywords
A phase 1 antigen dose escalation trial to evaluate safety, tolerability and immunogenicity of the leprosy vaccine candidate LepVax (LEP-F1 + GLA-SE) in healthy adults.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.12.050
Abstract: Healthy United States-based adult volunteers with no history of travel to leprosy-endemic countries were enrolled for the first-in-human evaluation of LepVax (LEP-F1 + GLA-SE). In total 24 volunteers participated in an open-labelclinicaltrial, with 21 receiving three injections… read more here.
Keywords: lepvax lep; antigen; lep; lepvax ... See more keywords
The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Human Biology"
DOI: 10.1080/03014460.2022.2134453
Abstract: Abstract Background Diabetes comprises a serious disease with significant growth in the number of cases in recent years. Here, we cover the gap in information between leptin (LEP) and type 1 diabetes in the Iranian… read more here.
Keywords: lep g2548a; impact; lep; type diabetes ... See more keywords
LEP as a potential biomarker in prognosis of breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000026896
Abstract: Abstract Purpose Obesity strongly affects the prognosis of various malignancies, including breast cancer. Leptin (LEP) may be associated with obesity and breast cancer prognosis. The purpose of our study was to determine the prognostic value… read more here.
Keywords: lep; prognosis; breast cancer; breast ... See more keywords
A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/7736485
Abstract: Leptin is a polypeptide hormone produced in the adipose tissue and governs many processes in the body. Recently, polymorphisms in the LEP gene revealed a significant change in body weight regulation, energy balance, food intake,… read more here.
Keywords: sheep lep; lep gene; nssnps sheep; lep ... See more keywords
Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP
Sign Up to like & getrecommendations! Published in 2021 at "Nanoscale Research Letters"
DOI: 10.1186/s11671-021-03475-5
Abstract: Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) expressing microRNAs have been highlighted in human diseases. However, the detailed molecular mechanism of hucMSCs-derived exosomal miR-18b-3p on preeclampsia (PE) remains further investigation. We aimed… read more here.
Keywords: derived exosomal; occurrence; human umbilical; lep ... See more keywords