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   Articles with "lepr" as a keyword



Association of leptin receptor polymorphisms with susceptibility of non‐small cell lung cancer: Evidence from 2249 subjects

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recommendations! Published in 2024 at "Cancer Medicine"

DOI: 10.1002/cam4.7178

Abstract: Non‐small cell lung cancer (NSCLC) is increasing dramatically. It is believed that energy metabolism‐related genes could play an important role in etiology of NSCLC. In this study, we sought to assess the correlation between three… read more here.

Keywords: cancer; occurrence; lepr; role ... See more keywords

Association analysis of polymorphisms in LEP (rs7799039 and rs2167270) and LEPR (rs1137101) gene towards the development of type 2 diabetes in North Indian Punjabi population.

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recommendations! Published in 2020 at "Gene"

DOI: 10.1016/j.gene.2020.144846

Abstract: OBJECTIVES Obesity is a major risk factor in aetiology of type 2 diabetes mellitus (T2DM). Leptin (LEP) is an anti-obesity hormone which regulates food intake, energy expenditure and glucose metabolism. The genetic variants in leptin… read more here.

Keywords: lepr; rs1137101; type diabetes; lep ... See more keywords

Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow.

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recommendations! Published in 2019 at "Cell stem cell"

DOI: 10.1016/j.stem.2018.11.022

Abstract: Hematopoietic stem cells (HSCs) are maintained in a perivascular niche in bone marrow, in which leptin receptor+ (LepR) stromal cells and endothelial cells synthesize factors required for HSC maintenance, including stem cell factor (SCF). An… read more here.

Keywords: lepr; leptin receptor; niche; lepr cells ... See more keywords

Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-03518-x

Abstract: Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study… read more here.

Keywords: lepr; common variants; association; lepr common ... See more keywords
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Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI‐SDS—A case series

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recommendations! Published in 2019 at "Pediatric Obesity"

DOI: 10.1111/ijpo.12577

Abstract: The clinical phenotype of patients with monogenic obesity due to mutations in the leptin receptor (LEPR) or melanocortin 4 receptor (MC4R) gene is characterized by impaired satiety and hyperphagia, leading to extreme, sometimes life‐threatening weight… read more here.

Keywords: lepr; obesity due; mc4r; satiety ... See more keywords

Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case–Control Study in Chinese Females

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.809570

Abstract: Background Leptin (LEP) plays a physiological role through its specific receptor (LEPR) and is involved in the occurrence and development of breast cancer. Our current study aimed at determining the influence of single-nucleotide polymorphisms (SNPs)… read more here.

Keywords: cancer; breast; breast cancer; cancer risk ... See more keywords

Impact of Bariatric Surgery on the Expression of Fertility-Related Genes in Obese Women: A Systematic Review of LEP, LEPR, MC4R, FTO, and POMC

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recommendations! Published in 2025 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms262110333

Abstract: Obesity is a multifaceted disorder influenced by various factors, with heredity being a significant contributor. Bariatric surgery is the most effective long-term intervention for morbid obesity and associated comorbidities, while outcomes vary significantly across individuals.… read more here.

Keywords: surgery; lepr; bariatric surgery; obesity ... See more keywords