Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1‐mediated deSUMOylation of SIRT3
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DOI: 10.1002/2211-5463.13539
Abstract: Bone marrow mesenchymal stem cells (BMSCs) are capable of multidirectional differentiation, and engrafted BMSCs can be used to replace damaged chondrocytes for treatment of intervertebral disc disease. However, chondroblast differentiation of implanted BMSCs is inhibited… read more here.
Keywords: sirt3; leptin; senp1; bmscs ... See more keywords
Obesity and the risk of Multiple Sclerosis. The role of Leptin
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51291
Abstract: To investigate the effects of leptin on different T‐cell populations, in order to gain more insight into the link between leptin and obesity. read more here.
Keywords: leptin obesity; risk multiple; leptin; obesity risk ... See more keywords
Leptin: A new therapeutic target for treatment of diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26580
Abstract: Leptin is an endogenous protein having 167 amino acids and is derived from adipocytes. It has tertiary structure that resembles with that of the pro‐inflammatory cytokines family. The fundamental role of leptin is to maintain… read more here.
Keywords: treatment; leptin; diabetes mellitus; role ... See more keywords
Enhancement of Lytic Activity by Leptin Is Independent From Lipid Rafts in Murine Primary Splenocytes
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DOI: 10.1002/jcp.25394
Abstract: Leptin, a pleiotropic adipokine, is known as a regulator of food intake, but it is also involved in inflammation, immunity, cell proliferation, and survival. Leptin receptor is integrated inside cholesterol‐rich microdomains called lipid rafts, which,… read more here.
Keywords: lytic activity; lipid rafts; leptin; membrane remodeling ... See more keywords
Diet-Induced Obesity and the Mechanism of Leptin Resistance.
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DOI: 10.1007/978-3-319-48382-5_16
Abstract: Leptin signaling blockade by chronic overstimulation of the leptin receptor or hypothalamic pro-inflammatory responses due to elevated levels of saturated fatty acid can induce leptin resistance by activating negative feedback pathways. Although, long form leptin… read more here.
Keywords: leptin resistance; leptin; mechanism leptin; leptin signaling ... See more keywords
Sex Differences in Leptin Control of Cardiovascular Function in Health and Metabolic Diseases.
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DOI: 10.1007/978-3-319-70178-3_6
Abstract: Leptin, the adipocyte-derived hormone identified in 1994 for its major role in the control of satiety and body weight regulation, is an adipokine secreted in a sex-specific manner. Although it has clearly been established that… read more here.
Keywords: cardiovascular function; control; leptin; control cardiovascular ... See more keywords
The Leptin Resistance.
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DOI: 10.1007/978-981-13-1286-1_8
Abstract: Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus,… read more here.
Keywords: energy; leptin resistance; leptin; obesity ... See more keywords
Leptin stimulates tissue rat mast cell pro-inflammatory activity and migratory response
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DOI: 10.1007/s00011-018-1171-6
Abstract: ObjectiveThe aim of this study was to determine whether leptin, a member of the adipocytokines involved in immune and inflammatory response regulation, may influence some aspects of mast cell biology.Materials and methodsExperiments were done in… read more here.
Keywords: response; mast cells; mast; leptin ... See more keywords
Leptin and soluble leptin receptor in association with gestational diabetes: a prospective case–control study
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-017-4617-0
Abstract: PurposeTo assess the association of serum leptin and its receptor (SLeptinR) with the risk of gestational diabetes mellitus (GDM) and to evaluate the longitudinal circulation of these peptides in pregnancy.MethodsThis study consisted of 53 subjects… read more here.
Keywords: leptin sleptinr; gestational diabetes; leptin; leptin receptor ... See more keywords
Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons
Sign Up to like & getrecommendations! Published in 2018 at "Brain Structure and Function"
DOI: 10.1007/s00429-018-1645-x
Abstract: Leptin is an adipose-derived hormone that controls appetite and energy expenditure. Leptin receptors are expressed on extra-hypothalamic ventrobasal (VB) and reticular thalamic (RTN) nuclei from embryonic stages. Here, we studied the effects of pressure-puff, local… read more here.
Keywords: gaba release; ventrobasal; leptin; reticular thalamic ... See more keywords
Leptin: an unappreciated key player in SLE
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DOI: 10.1007/s10067-019-04831-8
Abstract: Leptin is the forerunner of the adipokine superfamily and plays a key role in regulating energy expenditure and neuroendocrine function. Researches into leptin put emphasize not only on the metabolic role but also its immunoregulatory… read more here.
Keywords: key player; sle; leptin unappreciated; leptin ... See more keywords