Origins of Neonatal Leptin Deficiency in Preterm Infants
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric research"
DOI: 10.1038/s41390-019-0359-y
Abstract: BackgroundCord blood leptin increases with advancing gestation. Preterm delivery leads to premature separation from the maternal and placental leptin source predisposing infants to postnatal leptin deficiency, but this has not been fully described.MethodBlood leptin levels… read more here.
Keywords: leptin deficiency; preterm; leptin; leptin levels ... See more keywords
Abstract 137: Impact of Leptin Deficiency Compared to Neuronal Specific Leptin Receptor Deletion on Cardiometabolic Regulation
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.137
Abstract: The main goal of this study was to compare the impact of whole-body leptin deficiency with neuronal specific leptin receptor (LR) deletion on metabolic and cardiovascular regulation. Liver fat, diacylglycerol acyltransferase-2 (DGTA2) and CD36 protein… read more here.
Keywords: nestin cre; cre mice; mice; leptin deficiency ... See more keywords
Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Endocrinology"
DOI: 10.1530/eje-16-0821
Abstract: Context and aims Functional leptin deficiency is characterized by high levels of circulating immunoreactive leptin (irLep), but a reduced bioactivity of the hormone due to defective receptor binding. As a result of the fact that… read more here.
Keywords: functional leptin; monitor; leptin deficiency; leptin ... See more keywords
GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of endocrinology"
DOI: 10.1530/eje-18-0847
Abstract: The discovery of leptin, an adipocyte-secreted hormone, set the stage for unraveling the mechanisms dictating energy homeostasis, revealing adipose tissue as an endocrine system that regulates appetite and body weight. Fluctuating leptin levels provide molecular… read more here.
Keywords: energy homeostasis; harris prize; leptin deficiency; geoffrey harris ... See more keywords
Leptin deficiency-caused behavioral change – A comparative analysis using EthoVision and DeepLabCut
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1052079
Abstract: Introduction Obese rodents e.g., the leptin-deficient (ob/ob) mouse exhibit remarkable behavioral changes and are therefore ideal models for evaluating mental disorders resulting from obesity. In doing so, female as well as male ob/ob mice at… read more here.
Keywords: deficiency caused; caused behavioral; behavioral change; deeplabcut ... See more keywords