Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons
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DOI: 10.1016/j.celrep.2018.09.024
Abstract: Summary Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated with the augmentation of a voltage-gated… read more here.
Keywords: leptin; pomc; glucose production; pro opiomelanocortin ... See more keywords
Hypothalamic and Cell-Specific Transcriptomes Unravel a Dynamic Neuropil Remodeling in Leptin-Induced and Typical Pubertal Transition in Female Mice
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DOI: 10.1016/j.isci.2020.101563
Abstract: Summary Epidemiological and genome-wide association studies (GWAS) have shown high correlation between childhood obesity and advance in puberty. Early age at menarche is associated with a series of morbidities, including breast cancer, cardiovascular diseases, type… read more here.
Keywords: induced typical; leptin; leptin induced; female mice ... See more keywords
Mechanisms of leptin-induced endothelial dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000867
Abstract: Purpose of review Endothelial dysfunction is a major risk factor for many cardiovascular diseases, notably hypertension. Obesity increases the risk of endothelial dysfunction in association with increasing production of the adipokine leptin. Preclinical studies have… read more here.
Keywords: mechanisms leptin; induced endothelial; dysfunction; endothelial dysfunction ... See more keywords