A critical update on the leptin‐melanocortin system
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15765
Abstract: The discovery of leptin in 1994 was an “eureka moment” in the field of neurometabolism that provided new opportunities to better understand the central control of energy balance and glucose metabolism. Rapidly, a prevalent model… read more here.
Keywords: melanocortin system; leptin; leptin melanocortin; pomc neurons ... See more keywords
A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Skin pharmacology and physiology"
DOI: 10.1159/000516282
Abstract: BACKGROUND AND OBJECTIVES Gene mutations within the leptin-melanocortin signaling pathway lead to severe early-onset obesity. Recently, a phase 2 trial evaluated new pharmacological treatment options with the MC4R agonist setmelanotide in patients with mutations in… read more here.
Keywords: leptin melanocortin; melanocortin receptor; treatment; pigmentation ... See more keywords
Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.832911
Abstract: Monogenic obesity is a severe, genetically determined disorder that affects up to 1/1000 newborns. Recent reports on potential new therapeutics and innovative clinical approaches have highlighted the need for early identification of individuals with rare… read more here.
Keywords: genetic variants; genes leptin; melanocortin signalling; leptin melanocortin ... See more keywords
Polymorphisms of leptin-melanocortin system genes associated with obesity in an adult population from Barranquilla
Sign Up to like & getrecommendations! Published in 2020 at "Biomedica : revista del Instituto Nacional de Salud"
DOI: 10.7705/biomedica.4827
Abstract: Introduction: Obesity is considered a serious public health problem. Efforts have been directed to search for candidate genes such as LEP, LEPR, and MC4R involved in the leptin-melanocortin system. The neuroendocrine regulation of these genes… read more here.
Keywords: melanocortin system; leptin melanocortin; mc4r rs17782313; obesity ... See more keywords