Hydrogen sulfide prevents arecoline‐induced neurotoxicity via promoting leptin/leptin receptor signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11850
Abstract: Arecoline, a major alkaloid of the areca nut, has potential toxicity to the nervous system. Our previous study reveals that the neurotoxicity of arecoline involves in inhibited endogenous hydrogen sulfide (H2S) generation. Therefore, the present… read more here.
Keywords: signaling pathway; arecoline induced; leptin receptor; receptor signaling ... See more keywords
Novel leptin receptor signaling mutants identify location and sex‐dependent modulation of bone density, adiposity, and growth
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27726
Abstract: Leptin, a hormone primarily produced by adipocytes, contributes to the regulation of bone health by modulating bone density, growth and adiposity. Upon leptin binding, multiple sites of the long form of the leptin receptor (LepRb)… read more here.
Keywords: adiposity; leptin receptor; bone; bone density ... See more keywords
Leptin and soluble leptin receptor in association with gestational diabetes: a prospective case–control study
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-017-4617-0
Abstract: PurposeTo assess the association of serum leptin and its receptor (SLeptinR) with the risk of gestational diabetes mellitus (GDM) and to evaluate the longitudinal circulation of these peptides in pregnancy.MethodsThis study consisted of 53 subjects… read more here.
Keywords: leptin sleptinr; gestational diabetes; leptin; leptin receptor ... See more keywords
Leptin receptor gene (A/G) polymorphism rs1137101 and renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3320-1
Abstract: Leptin plays an important role in carcinogenesis as leptin/leptin receptor signaling promotes the angiogenesis, proliferation, and inhibits epithelial cell apoptosis. Variants in the leptin receptor gene have potential associations with renal cell carcinoma (RCC). We… read more here.
Keywords: gene; gene polymorphism; leptin receptor; polymorphism ... See more keywords
Amino acid-based compound activates atypical PKC and leptin receptor pathways to improve glycemia and anxiety like behavior in diabetic mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119839
Abstract: Differences in glucose uptake in peripheral and neural tissues account for the reduced efficacy of insulin in nervous tissues. Herein, we report the design of short peptides, referred as amino acid compounds (AAC) with and… read more here.
Keywords: insulin; amino acid; leptin; leptin receptor ... See more keywords
Immunolocalization of leptin and its receptor in the sheep ovary and in vitro effect of leptin on follicular development and oocyte maturation
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110506
Abstract: The aims of the study were to characterize leptin and it is receptor (LEPR) proteins immunoexpression in ovine ovaries and to evaluate the effects of leptin on development of secondary follicles cultivated in vitro. The… read more here.
Keywords: maturation; leptin; leptin receptor; follicular development ... See more keywords
Leptin receptor and fatty acid desaturase-2 gene variants affect fat, color and production profile of dry-cured hams.
Sign Up to like & getrecommendations! Published in 2020 at "Meat science"
DOI: 10.1016/j.meatsci.2020.108399
Abstract: The effects of LEPR (rs709596309C > T) and FADS2 (rs321384923A > G) single nucleotide polymorphisms on production and quality attributes in purebred Duroc dry-cured hams were examined. As compared to LEPR-C- hams, the LEPR-TT hams had more intramuscular fat… read more here.
Keywords: color; production; receptor fatty; leptin receptor ... See more keywords
Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma?
Sign Up to like & getrecommendations! Published in 2018 at "Pathology"
DOI: 10.1016/j.pathol.2018.01.007
Abstract: One of the challenges in differentiating chromophobe renal cell carcinoma (chRCC) from benign renal oncocytoma (RO) is overlapping morphology between the two subtypes. The aim of this study was to investigate the usefulness of expression… read more here.
Keywords: renal oncocytoma; renal cell; cell carcinoma; leptin receptor ... See more keywords
Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.11.022
Abstract: Hematopoietic stem cells (HSCs) are maintained in a perivascular niche in bone marrow, in which leptin receptor+ (LepR) stromal cells and endothelial cells synthesize factors required for HSC maintenance, including stem cell factor (SCF). An… read more here.
Keywords: lepr; leptin receptor; niche; lepr cells ... See more keywords
Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells
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DOI: 10.1016/j.stemcr.2020.10.001
Abstract: Summary The role of leptin receptor (OB-R) signaling in linking pluripotency with growth and development and the consequences of dysfunctional leptin signaling on progression of metabolic disease is poorly understood. Using a global unbiased proteomics… read more here.
Keywords: leptin receptor; protein synthesis; pluripotent stem; receptor signaling ... See more keywords
A novel and quick PCR-based method to genotype mice with a leptin receptor mutation (db/db mice)
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.52
Abstract: db/db mice is one of most widely used animal models in studying the cellular and molecular mechanisms of metabolic disorders, such as diabetes, hyperlipidemia, and obesity. The mice carry spontaneous point mutations in the gene… read more here.
Keywords: leptin receptor; method; pcr; mice ... See more keywords