Prognostic roles of leptin‐signaling proteins, PD‐L1, and tumor‐infiltrating lymphocytes in surgically‐resected biliary tract cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.27140
Abstract: Biliary tract cancers are rare, with a poor patient prognosis. Leptin and programmed death‐ligand 1 (PD‐L1) influence CD8+ and forkhead box P3 (FOXP3)+ lymphocytes, and thus, cancer cell growth. We aimed to define the prognostic… read more here.
Keywords: roles leptin; prognostic roles; leptin signaling; tract cancers ... See more keywords
Diet-Induced Obesity and the Mechanism of Leptin Resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-48382-5_16
Abstract: Leptin signaling blockade by chronic overstimulation of the leptin receptor or hypothalamic pro-inflammatory responses due to elevated levels of saturated fatty acid can induce leptin resistance by activating negative feedback pathways. Although, long form leptin… read more here.
Keywords: leptin resistance; leptin; mechanism leptin; leptin signaling ... See more keywords
Leptin/OB-R signaling is elevated in mice with Sjögren's syndrome and is implicated in disease pathogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.11.121
Abstract: Sjögren's syndrome (SjS) is a systemic autoimmune disease resulting in a severe dry mouth and dry eyes. Currently, care for patients with SjS is palliative, as no established therapeutics target the disease directly, and its… read more here.
Keywords: gren syndrome; mice gren; elevated mice; signaling elevated ... See more keywords
Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.04.005
Abstract: Objective Gsα couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating Gsα mutations lead to obesity in humans and mice. Mice with brain-specific Gsα deficiency also develop obesity with… read more here.
Keywords: energy; obesity; deficiency; thermogenesis ... See more keywords