Assessment of Phase 3 Randomized Clinical Trials Including Patients With Leptomeningeal Disease: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.7364
Abstract: This systematic review examines the proportion of patients with leptomeningeal disease included in phase 3 randomized clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma. read more here.
Keywords: clinical trials; systematic review; randomized clinical; phase randomized ... See more keywords
Intrathecal trastuzumab in the management of HER2+ breast leptomeningeal disease: a single institution experience
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4684-3
Abstract: PurposeLeptomeningeal disease is a rare and devastating presentation of advanced stage metastatic breast cancer with historically poor overall survival. We assessed the safety and feasibility of intrathecal (IT) trastuzumab in HER2+ leptomeningeal disease.MethodsA total of… read more here.
Keywords: intrathecal trastuzumab; leptomeningeal disease; breast; disease ... See more keywords
Leptomeningeal disease from melanoma-Poor prognosis despite new therapeutic modalities.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of cancer"
DOI: 10.1016/j.ejca.2021.02.016
Abstract: OBJECTIVE The development of leptomeningeal disease (LMD) among melanoma patients is associated with short survival. Unspecific clinical symptoms and imprecise diagnostic criteria often delay diagnosis. Because melanoma patients with LMD have been excluded from most… read more here.
Keywords: melanoma; leptomeningeal disease; diagnosis; disease ... See more keywords
A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac054
Abstract: Abstract Background Leptomeningeal disease (LMD) occurs as a late complication of several human cancers and has no rationally designed treatment options. A major barrier to developing effective therapies for LMD is the lack of cell-based… read more here.
Keywords: vitro vivo; csf ctcs; melanoma; patient derived ... See more keywords
Predictors of Leptomeningeal Disease Following Hypofractionated Stereotactic Radiotherapy for Intact and Resected Brain Metastases.
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-oncology"
DOI: 10.1093/neuonc/noz144
Abstract: BACKGROUND The objective was to evaluate the risk and predictors of developing leptomeningeal disease (LMD) in patients with brain metastases treated with 5-fraction hypofractionated stereotactic radiotherapy (HSRT). METHODS Patients treated with HSRT for intact brain… read more here.
Keywords: brain metastases; stereotactic radiotherapy; lmd; leptomeningeal disease ... See more keywords
Leptomeningeal disease in BRIP1-mutated pancreatic adenocarcinoma
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DOI: 10.1136/bcr-2022-249837
Abstract: Leptomeningeal disease is rare in pancreatic cancer and prognosis remains poor. Mutation profiles are now directing therapy to improve survival. We describe a case of leptomeningeal and brain metastasis in BRCA1 interacting protein 1, or… read more here.
Keywords: brip1; mutated pancreatic; pancreatic adenocarcinoma; brip1 mutated ... See more keywords
Retrospective review of metastatic melanoma patients with leptomeningeal disease treated with intrathecal interleukin-2
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2017-000283
Abstract: Objectives Metastatic melanoma patients with leptomeningeal disease (LMD) have an extremely poor prognosis, with a median survival measured in weeks, and few treatment options. Outcomes of a retrospective cohort of patients with LMD that were… read more here.
Keywords: leptomeningeal disease; patients leptomeningeal; metastatic melanoma; melanoma patients ... See more keywords
Discovery of a predictive protein biomarker for leptomeningeal disease after craniotomy and radiation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.2068
Abstract: 2068Background: Leptomeningeal disease (LMD) is a common but morbid disease progression after craniotomy for resection of brain metastases (BrM). LMD has been observed most commonly with breast cancer BrM, but the cellular mechanisms facilitating LMD… read more here.
Keywords: protein; leptomeningeal disease; disease; discovery predictive ... See more keywords
Case Report: Focal leptomeningeal disease, atypical cancer of unknown primary site.
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DOI: 10.12688/f1000research.122434.2
Abstract: Background: Leptomeningeal metastasis is an infrequent form of cancer expression, and it has a poor prognosis due to its torpid evolution and its challenging diagnosis. Case report: We report the case of a 68-year-old woman… read more here.
Keywords: focal leptomeningeal; case report; case; leptomeningeal disease ... See more keywords
Leptomeningeal disease: current diagnostic and therapeutic strategies
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DOI: 10.18632/oncotarget.20272
Abstract: Leptomeningeal disease has become increasingly prevalent as novel therapeutic interventions extend the survival of cancer patients. Although a majority of leptomeningeal spread occurs secondary to breast cancer, lung cancer, and melanoma, a wide variety of… read more here.
Keywords: disease current; leptomeningeal disease; diagnostic therapeutic; current diagnostic ... See more keywords
The Role of Immune Checkpoint Inhibitors in Leptomeningeal Disease: A Systematic Review
Sign Up to like & getrecommendations! Published in 2021 at "AntiCancer Research"
DOI: 10.21873/anticanres.15346
Abstract: Background/Aim: Leptomeningeal disease (LMD) is a debilitating complication of advanced malignancies. Immune-checkpoint inhibitors (ICIs) may alter disease course. We analyzed the role and toxicity of ICIs in LMD. Materials and Methods: We systematically reviewed the… read more here.
Keywords: role; immune checkpoint; leptomeningeal disease; checkpoint inhibitors ... See more keywords