Intra‐CSF topotecan in treatment of breast cancer patients with leptomeningeal metastases
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3422
Abstract: There are few treatment options for patients with leptomeningeal metastases (LM). read more here.
Keywords: leptomeningeal metastases; csf topotecan; treatment; patients leptomeningeal ... See more keywords
Leptomeningeal Metastases
Sign Up to like & getrecommendations! Published in 2018 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-018-0518-0
Abstract: Opinion statementTreatment options for leptomeningeal metastases are expanding with greater tolerability and efficacy than in the past. Improved knowledge of molecular subtypes of some cancers can guide in choosing more effective therapeutic options; however, physicians… read more here.
Keywords: leptomeningeal metastases;
Activity of EGFR Tyrosine Kinase Inhibitors in NSCLC With Refractory Leptomeningeal Metastases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2019.05.007
Abstract: Abstract Introduction Leptomeningeal metastases (LMs) are associated with dismal prognosis in NSCLC. Optimal management remains unknown in patients with EGFR-mutated NSCLC after initial tyrosine kinase inhibitor (TKI) failure. Methods We conducted a multicenter retrospective study… read more here.
Keywords: tyrosine kinase; leptomeningeal metastases; failure; clinical benefit ... See more keywords
Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation–Positive Non–Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.19.00457
Abstract: PURPOSE In this phase I study (BLOOM), osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), was evaluated in patients with leptomeningeal metastases (LMs) from EGFR-mutated (EGFRm) advanced non–small-cell lung cancer (NSCLC)… read more here.
Keywords: factor receptor; leptomeningeal metastases; epidermal growth; cell ... See more keywords
A new approach for leptomeningeal metastases: chemotherapy administered through lumbar intrathecal port.
Sign Up to like & getrecommendations! Published in 2021 at "Arquivos de neuro-psiquiatria"
DOI: 10.1590/0004-282x-anp-2020-0554
Abstract: BACKGROUND Intrathecal chemotherapy is a local therapeutic modality used for treatment of leptomeningeal metastases. However, the techniques currently used, i.e. repeated lumbar puncture and Ommaya reservoir, have certain disadvantages. Lumbar intrathecal port (LIP) placement is… read more here.
Keywords: chemotherapy; intrathecal port; intrathecal chemotherapy; leptomeningeal metastases ... See more keywords
Cauda equine syndrome as the primary symptom of leptomeningeal metastases from lung cancer: a case report and review of literature
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s165299
Abstract: Cauda equine syndrome (CES) is a neurological condition caused by compression of the cauda equine. Here, we demonstrate a case of CES as the primary symptom of leptomeningeal metastases from non-small cell lung carcinoma without… read more here.
Keywords: symptom leptomeningeal; leptomeningeal metastases; equine syndrome; cauda equine ... See more keywords
HER2+ esophageal carcinoma leptomeningeal metastases treated with intrathecal trastuzumab regimen.
Sign Up to like & getrecommendations! Published in 2023 at "CNS oncology"
DOI: 10.2217/cns-2022-0018
Abstract: Materials & methods: We recently reported the largest trial of breast cancer patients with HER2 positive leptomeningeal metastases (LM) treated with trastuzumab. An additional treatment indication was explored as part of a single institution retrospective… read more here.
Keywords: leptomeningeal metastases; intrathecal trastuzumab; esophageal carcinoma; trastuzumab ... See more keywords
Leptomeningeal metastases in glioma revisited: incidence and molecular predictors based on postcontrast fluid-attenuated inversion recovery imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurosurgery"
DOI: 10.3171/2022.9.jns221659
Abstract: OBJECTIVE Leptomeningeal metastases (LMs) in glioma have been underestimated given their low incidence and the lack of reliable imaging. Authors of this study aimed to investigate the real-world incidence of LMs using cerebrospinal fluid (CSF)-sensitive… read more here.
Keywords: leptomeningeal metastases; incidence; diagnosis; imaging ... See more keywords
Leptomeningeal Metastases from Solid Tumors: Recent Advances in Diagnosis and Molecular Approaches
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DOI: 10.3390/cancers13122888
Abstract: Simple Summary Leptomeningeal metastases are a devastating complication of solid tumors with poor survival, regardless of the type of treatments. The limited efficacy of targeted agents is due to the molecular divergence between leptomeningeal recurrences… read more here.
Keywords: leptomeningeal metastases; solid tumors; breast cancer; brain ... See more keywords
Neratinib and Capecitabine for the Treatment of Leptomeningeal Metastases from HER2-Positive Breast Cancer: A Series in the Setting of a Compassionate Program
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DOI: 10.3390/cancers14051192
Abstract: Simple Summary Leptomeningeal metastases represent an unmet need due to the lack of effective therapy and poor survival. The tyrosine kinase inhibitor, neratinib, has demonstrated promising activity against brain metastases from HER2-positive breast cancer, as… read more here.
Keywords: leptomeningeal metastases; breast cancer; her2 positive; treatment ... See more keywords
Leptomeningeal metastases originated from esophagogastric junction/gastric cancer: A brief report of two cases
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v10.i1.56
Abstract: Leptomeningeal carcinomatosis is a very rare manifestation in patients diagnosed with esophagogastric junction and gastric cancer. Its prognosis is ominous and therapy outcomes are disappointing. Herein, we present two patients; one initially diagnosed with gastric… read more here.
Keywords: leptomeningeal metastases; gastric cancer; junction gastric; cancer ... See more keywords