Sequencing of cerebrospinal fluid in non‐small‐cell lung cancer patients with leptomeningeal metastasis: A systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5163
Abstract: Leptomeningeal metastasis (LM) refers to the dissemination of malignant cells in the subarachnoid space, pia, and arachnoid mater and is a severe condition associated with metastatic solid tumors. The most common solid tumor that develops… read more here.
Keywords: lung cancer; non small; small cell; leptomeningeal metastasis ... See more keywords
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.025
Abstract: We molecularly dissected leptomeningeal metastasis, or spread of cancer to the cerebrospinal fluid (CSF), which is a frequent and fatal condition mediated by unknown mechanisms. We selected lung and breast cancer cell lines for the… read more here.
Keywords: leptomeningeal metastasis; complement component; metastasis; cancer ... See more keywords
Palliative shunt surgery for patients with leptomeningeal metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2018.03.008
Abstract: OBJECTIVES Leptomeningeal metastasis (LM) is associated with poor prognosis and affects the quality of life (QOL) of end-stage cancer patients. Severe headache associated with hydrocephalus causes reduced QOL. We investigated the clinical value of surgical… read more here.
Keywords: leptomeningeal metastasis; shunt surgery; months months; shunt ... See more keywords
NCMP-05. DECODING THE IMMUNE SYSTEM RESPONSE TO LEPTOMENINGEAL METASTASIS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.517
Abstract: For decades, the central nervous system was considered to be an immune privileged organ with limited access to systemic immunity. However, the leptomeninges, the cerebrospinal fluid (CSF)-filled anatomical structure that protects the brain and spinal… read more here.
Keywords: leptomeningeal metastasis; system; response; immune system ... See more keywords
Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis: a joint EORTC BTG and RANO effort.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac043
Abstract: BACKGROUND Validation of the 2016 RANO MRI scorecard for leptomeningeal metastasis failed for multiple reasons. Accordingly, this joint EORTC Brain Tumor Group and RANO effort sought to prospectively validate a revised MRI scorecard for response… read more here.
Keywords: assessment; rano; joint eortc; leptomeningeal metastasis ... See more keywords
18F-FDG PET/CT Findings of Leptomeningeal Metastasis in Nasopharyngeal Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000004499
Abstract: Abstract Nasopharyngeal carcinoma (NC) is an epithelial tumor with distinctive prevalence in East and Southeast Asia. Most patients with NC only experience regional metastasis. In cases of distant metastasis, prognosis is grim. Leptomeningeal spread of… read more here.
Keywords: metastasis; nasopharyngeal carcinoma; fdg pet; leptomeningeal metastasis ... See more keywords
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.09.20.508709
Abstract: Leptomeningeal metastasis is associated with dismal prognosis and has few treatment options. However, very little is known about the immune response to leptomeningeal metastasis. Here, by establishing an immunocompetent mouse model of breast cancer leptomeningeal… read more here.
Keywords: metastasis; vla suppression; senescence; leptomeningeal metastasis ... See more keywords
Leptomeningeal enhancement in magnetic resonance imaging predicts poor prognosis in lung adenocarcinoma patients with leptomeningeal metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14362
Abstract: To investigate the prognostic value of magnetic resonance imaging (MRI) findings in the prognosis of patients with leptomeningeal metastasis from lung adenocarcinoma. read more here.
Keywords: magnetic resonance; lung adenocarcinoma; resonance imaging; leptomeningeal metastasis ... See more keywords
Diagnostic Value of CYFRA 21-1 in the Cerebrospinal Fluid for Leptomeningeal Metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Disease Markers"
DOI: 10.1155/2017/2467870
Abstract: Cerebrospinal fluid (CSF) cytology has low sensitivity for leptomeningeal metastasis (LM); thus, new markers are needed to improve the diagnostic accuracy of LM. We measured carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA 21-1) in… read more here.
Keywords: leptomeningeal metastasis; cyfra; csf; csf serum ... See more keywords
Abstract 1190: Mimicking CAFs, pial cells support leptomeningeal metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1190
Abstract: Leptomeningeal metastasis (LM), the spread of cancer into cerebrospinal fluid (CSF)-filled coverings of the brain and spinal cord, is a dismal complication of cancer leading to rapid neurologic disability and death. While a diverse array… read more here.
Keywords: pial cells; cell; cancer; leptomeningeal metastasis ... See more keywords
Palliative lumboperitoneal shunt for leptomeningeal metastasis–related hydrocephalus: A case series
Sign Up to like & getrecommendations! Published in 2017 at "Palliative Medicine"
DOI: 10.1177/0269216316649128
Abstract: Background: Leptomeningeal metastasis–related hydrocephalus causes distress to patients with end-stage cancer through headache and other symptoms by elevating intracranial pressure, thus reducing quality of life. Ventriculoperitoneal shunt has been used as a treatment option in… read more here.
Keywords: leptomeningeal metastasis; metastasis related; lumboperitoneal shunt; case ... See more keywords