Panobinostat, a histone deacetylase inhibitor, suppresses leptomeningeal seeding in a medulloblastoma animal model.
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DOI: 10.18632/oncotarget.18132
Abstract: Leptomeningeal seeding is a strong negative prognostic factor for medulloblastoma (MB). The mechanism of leptomeningeal seeding is unclear but may involve epigenetic regulation. In this study, we evaluated the feasibility of a histone deacetylase (HDAC)… read more here.
Keywords: panobinostat; inhibitor; leptomeningeal seeding; histone deacetylase ... See more keywords