NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report
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DOI: 10.1161/atvbaha.117.309575
Abstract: Objective— Inflammasomes are multiprotein complexes, and their activation has been associated with cardiovascular disease. Inflammasome activation leads to secretion of caspase-1 by innate immune cells, resulting in the activation of interleukin-1&bgr;. Recently, a potent and… read more here.
Keywords: mcc950; lesion development; atherosclerotic lesion; nlrp3 inflammasome ... See more keywords