siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice
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DOI: 10.1126/scitranslmed.aay1063
Abstract: Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease. Perturbing plaque macrophages Macrophages in atherosclerotic lesions promote inflammation and plaque progression and are an attractive therapeutic target. Here, Tao et… read more here.
Keywords: plaque; plaque stability; sirna nanoparticles; lesional macrophages ... See more keywords