Abstract 4900: Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression
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DOI: 10.1158/1538-7445.am2023-4900
Abstract: EVI1 gene is located at 3q26.2 in the MECOM locus and encodes for a zinc-finger transcription factor. Chromosome translocation t(3;3) or inv(3) at 3q26 repositions the enhancer (E) of the tumor suppressor GATA2 to induce… read more here.
Keywords: targeting epigenetic; evi1 overexpression; 3q26 lesions; lesions evi1 ... See more keywords