A new purified Lawsoniaside remodels amyloid-β42 fibrillation into a less toxic and non-amyloidogenic pathway.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.005
Abstract: Mounting evidence indicates soluble Aβ42 oligomers as the most toxic species causing neuronal death which leads to the onset and progression of Alzheimer disease (AD). Recently, it has been found that neurotoxic Aβ42 oligomers grow… read more here.
Keywords: amyloid fibrillation; purified lawsoniaside; remodels amyloid; new purified ... See more keywords
Light-Enhanced Bacterial Killing and Less Toxic Cell Imaging: Multicationic Aggregation-Induced Emission Matters
Sign Up to like & getrecommendations! Published in 2018 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.8b03540
Abstract: The newly emerged pathogenic bacteria leads to the bactericides generations one by one, which is definitely a long-term and costly process. For the small organic molecule used as antibacterial materials, photostability, biomembrane penetrating ability, and… read more here.
Keywords: induced emission; dbpe dbo; aggregation induced; less toxic ... See more keywords
A colorful chemotherapy agent could be made less toxic.
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6499.18
Abstract: Doxorubicin, an old chemotherapy drug known as "the red devil" because of its distinctive hue and toxicity, remains a key treatment for many cancer patients. But a new study reports the drug can be tweaked… read more here.
Keywords: made less; chemotherapy agent; agent could; could made ... See more keywords
Bolaamphiphile Analogues of 12-bis-THA Cl2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00508-22
Abstract: While we face an acute threat from antibiotic resistant bacteria and a lack of new classes of antibiotic, there are many effective antimicrobials which have limited application due to concerns regarding their toxicity and which… read more here.
Keywords: less toxic; infection; bis tha; tha cl2 ... See more keywords