Molecular Dynamics Simulations for Deciphering the Structural Basis of Recognition of Pre-let-7 miRNAs by LIN28.
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DOI: 10.1021/acs.biochem.6b00837
Abstract: LIN28 protein inhibits biogenesis of miRNAs belonging to the let-7 family by binding to precursor forms of miRNAs. Overexpression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells.… read more here.
Keywords: let mirnas; molecular dynamics; pre let; recognition ... See more keywords
Expression of Concern on ‘DICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27’
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DOI: 10.1093/nar/gkac553
Abstract: When similar allegations were brought to the Editors’ attention again in late 2021, the journal re-opened the investigation. With newer techniques, the journal also identified potential concerns with Figure 2D. While the corresponding author works… read more here.
Keywords: expression concern; concern dicer; dependent biogenesis; let mirnas ... See more keywords
Antisense Oligonucleotides against Let-7 Enhance the Therapeutic Potential of Mesenchymal Stromal Cells
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DOI: 10.3390/ijms24108639
Abstract: Let-7 miRNAs have pleiotropic cellular functions in cell proliferation, migration, and regenerative processes. Here, we investigate whether the inhibition of let-7 miRNAs with antisense oligonucleotides (ASOs) can be a transient and safe strategy enhancing the… read more here.
Keywords: therapeutic potential; mesenchymal stromal; potential mesenchymal; antisense oligonucleotides ... See more keywords