LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "let radiation" as a keyword



A perspective on tumor radiation resistance following high-LET radiation treatment

Sign Up to like & get
recommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-024-05757-8

Abstract: High-linear energy transfer (LET) radiation is a promising alternative to conventional low-LET radiation for therapeutic gain against cancer owing to its ability to induce complex and clustered DNA lesions. However, the development of radiation resistance… read more here.

Keywords: let radiation; radiation resistance; radiation; high let ... See more keywords

DNA repair inhibitors sensitize cells differently to high and low LET radiation

Sign Up to like & get
recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-02719-9

Abstract: The aim of this study was to investigate effects of high LET α-radiation in combination with inhibitors of DDR (DNA-PK and ATM) and to compare the effect with the radiosensitizing effect of low LET X-ray… read more here.

Keywords: cancer; let; cell; radiation ... See more keywords

CRISPR/Cas9 generated DSB clusters mimic complex lesions induced by high-LET radiation and shift repair from c-NHEJ to mutagenic repair pathways

Sign Up to like & get
recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-22945-9

Abstract: DNA double-strand break (DSB) clusters are a hallmark of high-linear energy transfer (high-LET) radiation and are associated with pronounced biological effects, including reduced cell survival and elevated genomic instability. Our previous work in Chinese hamster… read more here.

Keywords: let radiation; repair; cell; high let ... See more keywords

DNA polymerase θ-mediated repair of high LET radiation-induced complex DNA double-strand breaks

Sign Up to like & get
recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad076

Abstract: Abstract DNA polymerase θ (POLQ) is a unique DNA polymerase that is able to perform microhomology-mediated end-joining as well as translesion synthesis (TLS) across an abasic (AP) site and thymine glycol (Tg). However, the biological… read more here.

Keywords: dna polymerase; dna; let; let radiation ... See more keywords