Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.039
Abstract: Background: Identifying genes that are essential for mouse embryonic development and survival through term is a powerful and unbiased way to discover possible genetic determinants of human developmental disorders. Characterising the changes in mouse embryos… read more here.
Keywords: highly variable; penetrance abnormal; abnormal phenotypes; variable penetrance ... See more keywords
A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48929-0
Abstract: The cell-cell adhesion protein E-cadherin (CDH1) is a tumor suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer (DGC) and… read more here.
Keywords: lethal compounds; novel synthetic; treatment; cell ... See more keywords
Predicting synthetic lethal interactions using conserved patterns in protein interaction networks
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006888
Abstract: In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific… read more here.
Keywords: patterns protein; lethal interactions; topology; conserved patterns ... See more keywords