A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells
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DOI: 10.1038/s41598-019-48929-0
Abstract: The cell-cell adhesion protein E-cadherin (CDH1) is a tumor suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer (DGC) and… read more here.
Keywords: lethal compounds; novel synthetic; treatment; cell ... See more keywords