Suspected seizure—survival of a lethal dose of the rodenticide alpha-chloralose
Sign Up to like & getrecommendations! Published in 2019 at "Der Anaesthesist"
DOI: 10.1007/s00101-019-00692-7
Abstract: A 58-year-old female was admitted due to a suspected seizure. A blue colored pharyngeal fluid was visualized during intubation, which is indicative of poisoning. Clinical research revealed an ingestion of 2.4 g of alpha-chloralose, a rodenticide… read more here.
Keywords: suspected seizure; rodenticide; alpha chloralose; lethal dose ... See more keywords
Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113670
Abstract: Human butyrylcholinesterase (E.C. 3.1.1.8) purified from blood plasma has previously been shown to provide protection against up to five and a half times the median lethal dose of an organophosphorus nerve agent in several animal… read more here.
Keywords: agent; human butyrylcholinesterase; butyrylcholinesterase; median lethal ... See more keywords
Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152787
Abstract: Warfare neurotoxicants such as sarin, soman or VX, are organophosphorus compounds which irreversibly inhibit cholinesterase. High-dose exposure with nerve agents (NA) is known to produce seizure activity and related brain damage, while less is known… read more here.
Keywords: sarin surrogate; sub lethal; exposure; lethal dose ... See more keywords
A little molecule that can disarm a lethal dose of flu virus
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/d41586-019-00783-w
Abstract: Drug candidate imitates a naturally occurring immune protein that binds to influenza virus.Drug candidate imitates a naturally occurring immune protein that binds to influenza virus. read more here.
Keywords: little molecule; flu virus; molecule disarm; dose flu ... See more keywords