The Impact of Protonation on Early Translocation of Anthrax Lethal Factor: Kinetics from Molecular Dynamics Simulations and Milestoning Theory.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b07419
Abstract: We report atomically detailed molecular dynamics simulations of the permeation of the lethal factor (LF) N-terminal segment through the anthrax channel. The N-terminal chain is unstructured and leads the permeation process for the LF protein.… read more here.
Keywords: molecular dynamics; anthrax; milestoning theory; protonation ... See more keywords
Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03186-2
Abstract: Burkholderia pseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that… read more here.
Keywords: lethal factor; basis specificity; molecular basis; deamidation eif4a ... See more keywords
Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells
Sign Up to like & getrecommendations! Published in 2018 at "Toxins"
DOI: 10.3390/toxins10070261
Abstract: Immunotoxins are being investigated as anti-cancer therapies and consist of a cytotoxic enzyme fused to a cancer targeting antibody. All currently used toxins function via the inhibition of protein synthesis, making them highly potent in… read more here.
Keywords: burkholderia lethal; cancer; anti cancer; neuroblastoma cells ... See more keywords
Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain
Sign Up to like & getrecommendations! Published in 2017 at "Toxins"
DOI: 10.3390/toxins9100298
Abstract: The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease.… read more here.
Keywords: protective antigen; anthrax; toxin; structure ... See more keywords