On Lethal Interactions: Differences Between Expressive and Instrumental Homicides in Mexico City
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Interpersonal Violence"
DOI: 10.1177/0886260517733280
Abstract: Research on violence in Mexico and Latin America suggests that, in part, due to state attempts to fight organized crime and the widespread availability of firearms, violence and homicides in general have experienced a recent… read more here.
Keywords: violence; interactions differences; use firearm; lethal interactions ... See more keywords
Predicting synthetic lethal interactions in human cancers using graph regularized self-representative matrix factorization
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3197-3
Abstract: Synthetic lethality has attracted a lot of attentions in cancer therapeutics due to its utility in identifying new anticancer drug targets. Identifying synthetic lethal (SL) interactions is the key step towards the exploration of synthetic… read more here.
Keywords: graph regularized; regularized self; matrix; lethal interactions ... See more keywords
Predicting synthetic lethal interactions using conserved patterns in protein interaction networks
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DOI: 10.1371/journal.pcbi.1006888
Abstract: In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific… read more here.
Keywords: patterns protein; lethal interactions; topology; conserved patterns ... See more keywords
Synthetic lethality guiding selection of drug combinations in ovarian cancer
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DOI: 10.1371/journal.pone.0210859
Abstract: Background Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but simultaneous loss of both gene functions results in lethality. Targeting synthetic… read more here.
Keywords: lethal interactions; drug; ovarian cancer; synthetic lethal ... See more keywords
SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment
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DOI: 10.3390/cancers11111682
Abstract: Synthetic lethality exploits the phenomenon that a mutation in a cancer gene is often associated with new vulnerability which can be uniquely targeted therapeutically, leading to a significant increase in favorable outcome. DNA damage and… read more here.
Keywords: tool; lethal interactions; synthetic lethality; cancer ... See more keywords
Harnessing Synthetic Lethal Interactions for Personalized Medicine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12010098
Abstract: Two genes are said to have synthetic lethal (SL) interactions if the simultaneous mutations in a cell lead to lethality, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill… read more here.
Keywords: synthetic lethal; harnessing synthetic; lethal interactions; personalized medicine ... See more keywords